arXiv AI

LERD: Latent Event-Relational Dynamics for Neurodegenerative Classification

arXiv:2602. 18195v2 Announce Type: replace-cross Abstract: Alzheimer's disease (AD) alters brain electrophysiology and disrupts multichannel EEG dynamics, making accurate and clinically useful EEG-based diagnosis increasingly important for screening and disease monitoring.

arXiv Machine Learning
Aug 31

Leveraging a Foundation Model for the EEG-Based Diagnosis of Alzheimer's Disease

The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.

By Maggie Lin, Chung-Lin Hou, Tzyy-Ping Jung
arXiv AI
Jun 8

LuMamba: Latent Unified Mamba for Electrode Topology-Invariant and Efficient EEG Modeling

arXiv:2603. 19100v2 Announce Type: replace Abstract: Electroencephalography (EEG) enables non-invasive monitoring of brain activity across clinical and neurotechnology applications, yet building foundation models for EEG remains challenging due to differing electrode topologies and computational scalability, as Transformer architectures incur quadratic sequence complexity.

By Dana\'e Broustail, Anna Tegon, Thorir Mar Ingolfsson, Yawei Li, Luca Benini
arXiv Machine Learning
Jun 8

One Loss to Rule Them All: Marked Time-to-Event for Structured EHR Foundation Models

arXiv:2602. 00541v2 Announce Type: replace Abstract: Clinical events captured in Electronic Health Records (EHR) are irregularly sampled and may consist of a mixture of discrete events and numerical measurements, such as laboratory values or treatment dosages.

By Zilin Jing, Vincent Jeanselme, Yuta Kobayashi, Simon A. Lee, Chao Pang, Aparajita Kashyap, Yanwei Li, Xinzhuo Jiang, Shalmali Joshi
arXiv Machine Learning
Jun 25

SDE-Driven Spatio-Temporal Hypergraph Neural Networks for Irregular Longitudinal fMRI Connectome Modeling in Alzheimer's Disease

arXiv:2603. 20452v2 Announce Type: replace Abstract: Longitudinal neuroimaging is essential for modeling disease progression in Alzheimer's disease (AD), yet irregular sampling and missing visits pose substantial challenges for learning reliable temporal representations.

By Ruiying Chen, Yutong Wang, Houliang Zhou, Wei Liang, Yong Chen, Lifang He
arXiv Machine Learning
Sep 17

Sparse Bayesian Modeling of EEG Channel Interactions Improves P300 Brain-Computer Interface Performance

The paper introduces a sparse Bayesian time‑varying regression framework that models pairwise EEG channel interactions and performs temporal feature selection for P300 brain‑computer interfaces. Using a relaxed‑thresholded Gaussian process prior, the method achieves a median character‑level accuracy of 96.4% on a public P300 speller dataset and outperforms both statistical and deep learning baselines. It also yields subgroup‑specific gains, notably for participants who abstain from alcohol, and improves median BCI‑Utility by over 10%, reaching peak throughput after only six sequence repetitions.

By Guoxuan Ma, Yuan Zhong, Moyan Li, Yuxiao Nie, Jian Kang
arXiv AI
Jun 19

SL-S4Wave: Self-Supervised Learning of Physiological Waveforms with Structured State Space Models

arXiv:2606. 19888v1 Announce Type: cross Abstract: Modeling long-sequence medical time series data, such as electrocardiograms (ECG), poses significant challenges due to high sampling rates, multichannel signal complexity, inherent noise, and limited labeled data.

By Feng Wu, Harsh Deep, Eric Lehman, Sanyam Kapoor, Guoshuai Zhao, Rahul Krishnan, Gari Clifford, Li-wei H Lehman