arXiv Machine Learning

Explainable Artificial Intelligence For The Detection and Characterisation of Stage B Heart Failure

arXiv:2606. 30665v1 Announce Type: cross Abstract: Stage B heart failure is characterized by asymptomatic structural or functional cardiac abnormalities.

arXiv AI
Aug 7

Tracing the Heart: An Evidence-Linked Pipeline for Heart-Failure Feature Engineering

arXiv:2608. 06366v1 Announce Type: new Abstract: Electronic health record (EHR) feature engineering is a major bottleneck in clinical research and AI, accounting for 39-45% of data scientists' workload.

By Soorya Ram Shimgekar, Michelle Hu, Dorisa Shehi, Daniel Kang, Roy Ka-Wei Lee, Koustuv Saha, Christian Poellabauer, Christopher Lee, Sajeev Singh, Piyum Zonooz, Navin Kumar, Zeeshan Ahmed, Priyadarshini Kachroo
arXiv Machine Learning
Jul 14

Artificial Intelligence Across the Cardiac Amyloidosis Diagnostic Pathway: From Single-Modality Detection to Multimodal Clinical Integration

arXiv:2607. 09948v1 Announce Type: cross Abstract: Cardiac amyloidosis (CA) is increasingly recognized but remains substantially underdiagnosed, because its clinical and imaging phenotype overlaps with more common cardiomyopathies.

By Diana Shadibaeva, Rochak Dhakal, Kui Zhang, Xiaofeng Yang, Saurabh Malhotra, Weihua Zhou
arXiv Machine Learning
Jul 28

Beyond Local Inspection: Global, Guideline-Grounded Evaluation of Post-hoc XAI Methods for ECG Classification

arXiv:2607. 24035v1 Announce Type: cross Abstract: Explainable AI (XAI) is used to assess whether artificial intelligence models rely on meaningful patterns, yet explanations that appear plausible for individual predictions may systematically misrepresent model behavior.

By Nils Gumpfer, Michael Guckert, Samuel Sossalla, Birgit A{\ss}mus, Jennifer Hannig
arXiv Machine Learning
Sep 18

Interpretable and Calibrated Classification of Clinical Data Using Supervised Feature Binarization

The paper introduces a statistically grounded framework for interpretable, rule-based clinical classification using Bernoulli Naïve Bayes (BNB). It employs supervised chi‑square‑guided binarization to convert continuous medical variables into binary indicators, enabling BNB to handle continuous data while maintaining transparency. On three benchmark datasets—Pima Indians Diabetes, Wisconsin Breast Cancer, and Heart Failure Prediction—the method achieved AUCs of 0.800, 0.984, and 0.919, respectively, and demonstrated reliable probability calibration through cross‑validated analysis and post‑hoc beta calibration.

By Antony Garcia, Adrian Noriega, Gabrielle Britton, Xinming Huang
arXiv Machine Learning
Aug 20

Transforming Heart Disease Prediction with Advanced Machine Learning Techniques

The study evaluates several machine‑learning classifiers for predicting heart disease using two public datasets, each with 14 health‑related attributes. Performance metrics such as MAE, RAE, accuracy, precision, recall, and F‑measure were used, revealing that SVM performed best on the UCI data while Simple Cart excelled on the Kaggle data. The authors conclude that well‑tuned ML models can aid early heart‑disease diagnosis and suggest future work on hybrid methods and newer datasets.

By Sami Ullah, Muhammad Mohsin Khan
arXiv Machine Learning
Sep 22

ORION-CMR: On-scanner Reporting with Integrated Foundation Model for End-to-End Cardiac MRI Analysis and Interpretation

ORION‑CMR is a scanner‑native, end‑to‑end foundation model for cardiac MRI that performs sequence classification, ventricular function assessment, LGE detection, disease classification, and generates reports in about 90 seconds. Trained on 12.9 million images, it outperformed supervised baselines and a prior CMR foundation model, achieving state‑of‑the‑art LGE classification and scar segmentation. In a multi‑vendor clinical cohort, it reached an AUC of 0.96 for normal‑vs‑abnormal detection and 0.88 for multiclass disease classification, with generated reports agreeing 81.4% with expert interpretation.

By Omer Burak Demirel, Kelly K. Horst, Alessio Perazzolo, Elisa Bruno, Kenan Kaya, Rongzhen Ouyang, Enas Ahmed, Jouke Smink, Spencer L. Waddle, Zainudeen Kallumpurath, Tzu Cheng Chao, Dinghui Wang, Steve G. Langer, Timothy L. Kline, Panagiotis Korfiatis, Jacinta Browne, Ivana Isgum, Tim Leiner
arXiv AI
Sep 2

AI Morbidity and Mortality: A Framework for Clinical AI Failure Review

AI Morbidity and Mortality (AI M&M) is a structured, blameless framework designed to review clinical AI failures. It combines standardized case intake, evidence preservation, investigator reconstruction, tool‑in‑loop attribution, and corrective‑action tracking, classifying each event across four linked dimensions: Trigger, Mechanism, Clinical Pathway, and Corrective Action. The authors demonstrate the framework with five outpatient medication and clinical decision‑support cases, achieving full agreement among reviewers on all classification axes.

By Paulius Mui, Dean F. Sittig, Steve Labkoff, Sanjay Basu
arXiv AI
Jun 2

CardioLens: Revealing the Clinical Reality Gap of MLLMs via Multi-Sequence Cardiac MRI Evaluations

arXiv:2606. 00123v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) have shown strong performance on public medical benchmarks, yet existing evaluations often remain weak proxies for clinical use, relying on isolated inputs and simplified recognition-style tasks.

By Zixian Su, Hongkai Zhang, Fan Gao, Encheng Su, Taiping Qu, Jingwei Guo, Nan Zhang, Hui Wang, Zhen Zhou, Kairui Bo, Yan Chen, Yue Ren, Shuai Li, Lei Xu, Henggui Zhang
arXiv Machine Learning
Jul 21

ECG-LLM: Foundation Model for ECG-Based Cardiac Reasoning

arXiv:2607. 16323v1 Announce Type: cross Abstract: Electrocardiography (ECG) is an inexpensive, standard-of-care test for cardiac symptoms, but front-line triage often lacks immediate access to definitive imaging such as echocardiography (ECHO) or cardiac magnetic resonance (CMR).

By Alexander Selivanov, Friederike Jungmann, Jan Kehrer, Karl-Ludwig Laugwitz, Eimo Martens, Daniel Rueckert