arXiv Machine Learning

Negative controls reveal volume-driven confounding in radiomics and imaging foundation model features

arXiv:2607. 28423v1 Announce Type: cross Abstract: Radiomics and imaging foundation models promise non-invasive biomarkers of tumour biology, yet predictive signatures may reflect tumour volume or acquisition artifacts rather than meaningful image structure.

arXiv Computer Vision
Sep 23

Radiomics--Foundation Fusion for Interpretable RCC Classification: Internal Benchmarking and Exploratory External Transfer

arXiv:2609.26578v1 Announce Type: new Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced CT remains clinically challenging because clear cell...

By Yuan Liang, Fangyijie Wang, Kathleen M. Curran, Gu\'enol\'e Silvestre, Sourav Bhattacharjee, Abraham Campbell
arXiv AI
Jul 8

CONFLUX: A Latent Diffusion Model for 3D Chest-CT Synthesis with RL Post-Training

arXiv:2607. 02998v2 Announce Type: replace-cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.

By Max Van Puyvelde, Halil Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv AI
Jul 7

An Interpretable Deep Learning Framework for Discovery and Clinical Validation of Deep Radiomic Signatures in Tumor Classification

arXiv:2607. 03593v1 Announce Type: cross Abstract: Imaging signatures are quantitative features extracted from medical images that provide clinically meaningful information for tumor diagnosis, characterization, prognosis, and treatment planning.

By Chengkun Sun, Jinqian Pan, Renjie Liang, Zhengkang Fan, Xin Miao, Yi Guo, Mei Liu, Muxuan Liang, Russell Terry, Jie Xu
arXiv AI
Jul 7

CONFLUX: A Latent Diusion Model for 3D Chest-CT Synthesis with RL Post-Training

arXiv:2607. 02998v1 Announce Type: cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.

By Max Van Puyvelde, Halil Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv Machine Learning
Jul 28

Trustworthy Medical Segmentation: Uncertainty-Aware U-Net Evaluation Under Clinical Image Degradation

arXiv:2607. 22727v1 Announce Type: cross Abstract: Medical image segmentation models often report high benchmark accuracy under ideal imaging conditions, yet their failures under clinical degradation can be quiet: sensor noise, patient motion, low- resolution acquisition, and contrast variability may all alter model behavior without producing an obvious warning.

By Pranav Kaliaperumal, Manisha Kaliaperumal
arXiv Machine Learning
Jul 2

Foundation Models vs. Radiomics for Lung Computed Tomography: A Benchmark of Feature Extractors, Classification Heads, and Segmentation Choices

arXiv:2607. 01001v1 Announce Type: cross Abstract: Radiomics is the established approach for CT-based lung cancer phenotyping, yet comparisons with foundation models rarely isolate contributions of feature extractor, classification head, and segmentation choice, or test cross-cohort robustness.

By Nils Neukirch, Martin Maurer, Nils Strodthoff
arXiv Computer Vision
Sep 24

nnFoundation: 3D Foundation Models for Radiology

nnFoundation introduces complementary convolutional and transformer-based 3D foundation models for radiology, trained on 2.1 million CT, MRI, and PET volumes from 125 datasets. The models are evaluated on 108 tasks—including segmentation, detection, classification, report generation, and image retrieval—under domain shift, low-data, and low-compute scenarios, consistently outperforming prior 3D foundation models and training from scratch. Performance varies by task type, with convolutional models excelling at spatially localized tasks and transformer models at global semantic reasoning, and dynamic alignment with dataset characteristics further enhances transferability.

By Constantin Ulrich Harsy, Tassilo Wald, Karol Gotkowski, Yannick Kirchhoff, Marcel Knopp, Maximilian Rokuss, Elisa Stegmeier, Philipp Schader, Dasha Trofimova, Raphael Stock, Kim-Celine Kahl, Stephen Schaumann, Selen Erkan, David Zimmerer, Stefan Denner, Moritz Langenberg, Sebastian Ziegler, Katharina Eckstein, Maximilian Fischer, Jonathan Suprijadi, B\'alint Kov\'acs, Benjamin Hamm, Anand Deshpande, Dimitrios Bounias, Nico Disch, Shuhan Xiao, Jessica K\"achele, Jan Sellner, Rajesh Baidya, Jeremias Traub, Lars Kr\"amer, Maximilian Zenk, Tim R\"adsch, Stefan Dvoretskii, Robin Peretzke, Jonathan Deissler, Alexandra Ertl, Partha Ghosh, Kris Dreher, Stefan Dinkelacker, Annika Reinke, Evangelia Christodoulou, Numan Saeed, Yoland Savriama, Santiago Estrada, David K\"ugler, Laura Alexandra Daza Barragan, Cristina Isabel Gonzalez Osorio, Jan Peeken, Michael Baumgartner, Marvin Teichmann, Guillaume Chabin, Matthias Kirchler, Valentin Koch, for the ALFA study, Markus Hohenhaus, Dimitri Koslov, Nina Decker, Mohammad Yaqub, Arnd Heuser, Martin Reuter, Julia A. Schnabel, Tobias Heimann, Florin Ghesu, Paul Brachmann, Claus P. Heu{\ss}el, Alexander Radbruch, Gianluca Brugnara, Aditya Rastogi, Martha Foltyn-Dumitru, Heinz-Peter Schlemmer, Ignaz Reicht, Julius C. Holzschuh, Michael Bach, Bram Stieltjes, Kai Schlamp, Lena Maier-Hein, Marco Nolden, Ralf Floca, Paul F. J\"ager, Philipp Vollmuth, Fabian Isensee, Klaus H. Maier-Hein