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arXiv:2609.26463v1 Announce Type: new Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced computed tomography remains clinically challenging. R...
arXiv:2609.26492v1 Announce Type: new Abstract: Radiomics provides quantitative descriptions of tumour appearance that may complement disease-specific foundation models in small labelled cohorts. We...
The study introduces RCC-Align, a cross‑modal contrastive learning framework that aligns paired histopathology whole‑slide images and CT scans to enhance noninvasive grading of clear cell renal cell carcinoma (ccRCC). Using patient‑level five‑fold cross‑validation on TCGA and CPTAC cohorts, RCC‑Align achieved an AUC of 0.601 and AUPRC of 0.599 for low‑ versus high‑grade ccRCC classification, outperforming CT‑only baselines and showing stronger WSI‑CT embedding alignment. The approach relies solely on CT at inference, potentially aiding grading when biopsy is unsafe or limited by tumor heterogeneity.
The paper introduces a semantic‑guided multimodal preprocessing technique that fuses nuclei classification maps with RGB histopathology images for Vision Transformer‑based grading of clear cell renal cell carcinoma. By concatenating classification map channels and applying multiplicative modulation, the method achieves a balanced accuracy of 0.916, markedly surpassing an RGB‑only baseline (0.707) and prior max‑voting approaches (0.427). Sensitivity analysis shows the 21‑percentage‑point improvement remains robust under simulated perturbations matching current nuclei classifier error rates, indicating effective use of imperfect nuclear‑level information.
Clear cell renal cell carcinoma (CCRCC) grading is essential for treatment planning, yet existing approaches either analyze patch-level images directly or focus solely on nuclei-level classification,...
arXiv:2608. 07857v1 Announce Type: cross Abstract: Foundation models provide transferable CT representations, but predictions based directly on these embeddings are difficult to interpret.