arXiv Computation and Language

PRISMATIC : Prescription Risk Inspection System for Multi-Agent Treatment Interaction in Clinical Decision-Making

arXiv AI
Aug 11

Coupled Graph--Policy Distillation for Personalized Medication Safety in Older Adults with Multimorbidity

arXiv:2608. 09443v1 Announce Type: new Abstract: Large language model (LLM) agents can support medication review between clinical visits, but safe choices for older adults with multimorbidity depend on conditions, medications, and geriatric risks that users may omit.

By Zihan Wang, Anglin Liu, Rongyi Wang, Dantong Li, Yi Lu, Siqing Yuan, Hongxia Xu, Zhongtian Long, Jintai Chen
arXiv AI
Jun 16

Toward Vibe Medicine: A Self-Evolving Multi-Agent Framework for Clinical Decision Support

arXiv:2606. 15504v1 Announce Type: new Abstract: In recent years, the advances of large language models and autonomous agents have revolutionized the healthcare field, facilitating diagnosis and improving treatment results.

By Qianxue Zhang, Yiming Ren, Shihuan Qin, Xiao Zhang, Liao Zhang, Jinyang Huang, Zhengliang Liu, Chenbin Liu, Hongying Feng, Jingyuan Chen, Yuzhen Ding, Weihang You, Hanqi Jiang, Yi Pan, Yifan Zhou, Junhao Chen, Lifeng Chen, Wei Liu, Tianming Liu, Zengren Zhao, Lian Zhang
arXiv AI
Sep 15

ClinicalReTrial: Clinical Trial Redesign with Self-Evolving Agents

ClinicalReTrial is a multi‑agent AI system that treats clinical trial protocol optimization as an iterative redesign problem on textual documents. It combines failure diagnosis, safety‑aware modifications, and candidate evaluation within a closed‑loop, reward‑driven framework, using a predictive model as a simulation environment for low‑cost, dense feedback. The system achieves a 56.7% conversion of failed protocols to predicted successes, with a 7.4% average success probability increase at a negligible cost, and its redesign patterns align with real‑world expert changes.

By Sixue Xing, Kerui Wu, Xuanye Xia, Haoyu He, Meng Jiang, Jintai Chen, Tianfan Fu
arXiv AI
6d ago

HEM-Med: A Hierarchical Agentic Memory Framework for Safe Multi-Center Medication Recommendation

HEM-Med introduces a hierarchical agentic memory framework for safe multi‑center medication recommendation, addressing two key gaps in existing methods. It disentangles cross‑hospital clinical experience from hospital‑specific prescribing patterns via a hierarchical memory module, and incorporates a safety‑aware medication set generation module that considers drug‑drug interactions and local formulary constraints. Experiments on a real‑world multi‑center eICU dataset demonstrate that HEM‑Med outperforms representative transfer learning, LLM‑based, and MR baselines in both recommendation accuracy and safety.

By Min Xiao, Jin Li, Shoujin Wang, Yeguang Zhen, Yishuo Li, Wenpeng Lu
arXiv AI
Jun 16

MedCollab: IBIS-Guided Multi-Agent Collaboration with Hierarchical Disease Relation Chains for Clinical Diagnosis

arXiv:2603. 01131v3 Announce Type: replace-cross Abstract: Clinical diagnosis is a gradual process of evidence integration, in which physicians move from symptoms and medical history to examinations, competing hypotheses, disease relations, and treatment decisions.

By Yuqi Zhan, Xinyue Wu, Tianyu Lin, Yutong Bao, Xiaoyu Wang, Weihao Cheng, Huangwei Chen, Feiwei Qin, Zhu Zhu
arXiv AI
Sep 2

AI Morbidity and Mortality: A Framework for Clinical AI Failure Review

AI Morbidity and Mortality (AI M&M) is a structured, blameless framework designed to review clinical AI failures. It combines standardized case intake, evidence preservation, investigator reconstruction, tool‑in‑loop attribution, and corrective‑action tracking, classifying each event across four linked dimensions: Trigger, Mechanism, Clinical Pathway, and Corrective Action. The authors demonstrate the framework with five outpatient medication and clinical decision‑support cases, achieving full agreement among reviewers on all classification axes.

By Paulius Mui, Dean F. Sittig, Steve Labkoff, Sanjay Basu