arXiv:2608. 09443v1 Announce Type: new Abstract: Large language model (LLM) agents can support medication review between clinical visits, but safe choices for older adults with multimorbidity depend on conditions, medications, and geriatric risks that users may omit.
By Zihan Wang, Anglin Liu, Rongyi Wang, Dantong Li, Yi Lu, Siqing Yuan, Hongxia Xu, Zhongtian Long, Jintai Chen
arXiv:2609.13543v1 Announce Type: new
Abstract: LLM agents are predominantly benchmarked on short, single-task trajectories, yet real deployments run for hours under contention, surfacing a different...
By Grace Chang Yuan, Xiaoman Zhang, Sung Eun Kim, Luyang Luo, Pranav Rajpurkar
arXiv:2606. 15504v1 Announce Type: new Abstract: In recent years, the advances of large language models and autonomous agents have revolutionized the healthcare field, facilitating diagnosis and improving treatment results.
By Qianxue Zhang, Yiming Ren, Shihuan Qin, Xiao Zhang, Liao Zhang, Jinyang Huang, Zhengliang Liu, Chenbin Liu, Hongying Feng, Jingyuan Chen, Yuzhen Ding, Weihang You, Hanqi Jiang, Yi Pan, Yifan Zhou, Junhao Chen, Lifeng Chen, Wei Liu, Tianming Liu, Zengren Zhao, Lian Zhang
ClinicalReTrial is a multi‑agent AI system that treats clinical trial protocol optimization as an iterative redesign problem on textual documents. It combines failure diagnosis, safety‑aware modifications, and candidate evaluation within a closed‑loop, reward‑driven framework, using a predictive model as a simulation environment for low‑cost, dense feedback. The system achieves a 56.7% conversion of failed protocols to predicted successes, with a 7.4% average success probability increase at a negligible cost, and its redesign patterns align with real‑world expert changes.
By Sixue Xing, Kerui Wu, Xuanye Xia, Haoyu He, Meng Jiang, Jintai Chen, Tianfan Fu
arXiv:2605. 09366v3 Announce Type: replace Abstract: Transforming neuroimaging data into clinically actionable biomarkers is a knowledge-intensive and labor-intensive process.
By Keqi Han, Songlin Zhao, Yao Su, Xiang Li, Yixuan Yuan, Lifang He, Carl Yang
HEM-Med introduces a hierarchical agentic memory framework for safe multi‑center medication recommendation, addressing two key gaps in existing methods. It disentangles cross‑hospital clinical experience from hospital‑specific prescribing patterns via a hierarchical memory module, and incorporates a safety‑aware medication set generation module that considers drug‑drug interactions and local formulary constraints. Experiments on a real‑world multi‑center eICU dataset demonstrate that HEM‑Med outperforms representative transfer learning, LLM‑based, and MR baselines in both recommendation accuracy and safety.
By Min Xiao, Jin Li, Shoujin Wang, Yeguang Zhen, Yishuo Li, Wenpeng Lu
arXiv:2603. 01131v3 Announce Type: replace-cross Abstract: Clinical diagnosis is a gradual process of evidence integration, in which physicians move from symptoms and medical history to examinations, competing hypotheses, disease relations, and treatment decisions.
By Yuqi Zhan, Xinyue Wu, Tianyu Lin, Yutong Bao, Xiaoyu Wang, Weihao Cheng, Huangwei Chen, Feiwei Qin, Zhu Zhu
arXiv:2608.23397v1 Announce Type: new
Abstract: Interactive clinical agents must gather decisive evidence and convert it into grounded actions under partial observability. A correct final diagnosis a...
By Ruoyu Wu, Shenfu Xie, Yinqian Sun, Haibo Tong, Feifei Zhao
arXiv:2608.21864v1 Announce Type: cross
Abstract: The current progress of Clinical Vision Large Language Models (C-VLLMs) has substantially improved digital diagnostics, still these frameworks often...
By Md Asaduzzaman Jabin, Zihao Wu, Tianming Liu
Medication recommendation (MR) is critical for clinical decision support. While existing MR methods are mostly designed for single-center learning, where only one independent hospital is involved, mul...
arXiv:2608. 03190v1 Announce Type: new Abstract: Neuro-oncology decisions require coordinated interpretation of serial MRI, pathology, molecular markers, treatment history, performance status, and evolving guidelines.
By Yantong Liu, Zheyu Zhang, Runpeng Liu, Mu Xitang, Seong-Yoon Shin, Hyun-Ae Lee
AI Morbidity and Mortality (AI M&M) is a structured, blameless framework designed to review clinical AI failures. It combines standardized case intake, evidence preservation, investigator reconstruction, tool‑in‑loop attribution, and corrective‑action tracking, classifying each event across four linked dimensions: Trigger, Mechanism, Clinical Pathway, and Corrective Action. The authors demonstrate the framework with five outpatient medication and clinical decision‑support cases, achieving full agreement among reviewers on all classification axes.
By Paulius Mui, Dean F. Sittig, Steve Labkoff, Sanjay Basu