arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.
By Muge Zhang, Muhammad Ali Khaliq, Jamal Alsakran, Byeong Kil Lee, Jeeho Ryoo
The paper investigates fiber bundle segmentation in macaque tracer histology, comparing traditional BCE‑Dice loss with topology‑aware losses such as clDice, Betti matching, and Topograph using a frozen DINOv3 backbone. While BCE‑Dice yields the highest Dice score, Topograph achieves comparable Dice with lower topological error and fewer false positives. The authors also introduce Excess32, a spatial diagnostic that reveals oversegmentation issues not captured by conventional detection metrics, demonstrating that detection metrics alone are insufficient for evaluating segmentation quality.
By Joselyn Romero Avila, Kyriaki-Margarita Bintsi, Ermias Habte, Julia F. Lehman, Suzanne N. Haber, Anastasia Yendiki
Fiber tractography's ability to reconstruct the brain's structural pathways, has made it a crucial component of modern neuroimaging, enabling detailed, non-invasive mapping of structural connectivity and supporting a wide range of neurological research and clinical applications. However, despite its importance, tractography remains a challenging task due to the inherent complexity of white matter structure and its susceptibility to false positives, which can lead to the misrepresentation of critical pathways.
arXiv:2609.31431v1 Announce Type: new
Abstract: Accurate segmentation of axons in 3D microscopy data is important for analyzing white-matter organization, but dense ground truth labels are expensive...
By Edward Gaibor, Kyriaki-Margarita Bintsi, Carmen Luz Leiva Ureta, Zayneb Bellatif, Chiara Maffei, Wenze Li, Elizabeth Hillman, Ya\"el Balbastre, Anastasia Yendiki
The paper presents a systematic comparison of recurrent neural networks and Transformer models for iterative diffusion MRI tractography, focusing on training strategies, input representations, and hyperparameter tuning. It introduces a generation‑validation phase that provides streamline‑level supervision, enabling the models to achieve the best performance reported on the ISMRM2015 challenge dataset. The study also evaluates the effects of missing bundles, noisy training data, and invalid fibers, and demonstrates applicability to in‑vivo data from the Tractoinferno database.
By Emmanuelle Renauld, Philippe Poulin, Hugo Larochelle, Antoine Th\'eberge, Maxime Descoteaux
Machine learning (ML) has emerged as a promising approach for improving diffusion MRI (dMRI) tractography, a task that remains limited by the intrinsic tension between local diffusion information and...