arXiv Computation and Language

Learning Diagnostic Reasoning for Decision Support in Toxicology

The paper introduces DeToxR, a reinforcement‑learning‑enhanced large language model designed to support decision making in acute toxicology cases. It fuses unstructured narratives from paramedics and patients with structured vital‑sign data to predict co‑ingested substances across 14 classes. In preliminary validation, DeToxR outperforms baseline models, achieving higher micro‑F1 and recall scores for poison identification.

arXiv Machine Learning
Jun 2

OncoReason: Structuring Clinical Reasoning in LLMs for Robust and Interpretable Survival Prediction

arXiv:2510. 17532v2 Announce Type: replace-cross Abstract: Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data.

By Raghu Vamshi Hemadri, Geetha Krishna Guruju, Kristi Topollai, Anna Ewa Choromanska
arXiv AI
Jul 21

Enhancing LLMs' Clinical Reasoning with Real-World Data from a Nationwide Sepsis Registry

arXiv:2505. 02722v2 Announce Type: replace Abstract: Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited.

By Junu Kim, Chaeeun Shim, Sungjin Park, Su Yeon Lee, Gee Young Suh, Chae-Man Lim, Seong Jin Choi, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Sejoong Kim, Chami Im, Dong-Wan Kang, Yong Soo Kim, Hee-Joon Bae, Sung Yoon Lim, Han-Gil Jeong, Edward Choi
arXiv Computation and Language
Aug 28

CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models

CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models proposes a new framework to improve medical reasoning in LLMs. It introduces two key conditions—Causal Sufficiency and Proximal Learnability—to curate high-quality training trajectories, using agreement-based self-verification and dynamic entropy bounds. Experiments on medical multimodal and text-only benchmarks show that CARE outperforms competitors, reducing incorrect reasoning and enhancing training stability.

By Yucheng Zhou, Peng Luo, Qianning Wang, Chengzhong Xu, Jianbing Shen
arXiv Machine Learning
Jun 4

VentAgent: When LLMs Learn to Breathe -- Multi-Objective Arbitration for ARDS Ventilation

arXiv:2606. 04632v1 Announce Type: new Abstract: Mechanical ventilation for Acute Respiratory Distress Syndrome (ARDS) requires balancing competing physiological goals, including oxygenation, lung protection, and acid-base homeostasis.

By Teqi Hao, Yuxuan Fu, Xiaoyu Tan, Shaojie Shi, Bohao Lv, Yinghui Xu, Xihe Qiu
arXiv Machine Learning
Sep 14

Reinforcement Learning over Patient Trajectories for Clinical Reasoning in EHR Foundation Models

The paper proposes a reinforcement learning (RL) fine‑tuning framework for electronic health record (EHR) foundation models, treating them as generative policies over patient trajectories. By framing clinical prediction tasks such as hospital readmission as event‑conditioned, time‑windowed reasoning problems and designing time‑aware, rollout‑sensitive rewards, the authors show that RL fine‑tuning consistently outperforms pre‑trained backbones and strong baselines. The approach enables smaller models to surpass larger pre‑trained models in data‑limited settings, induces positive transfer across tasks, and produces trajectories with stronger structural and semantic alignment to ground truth, improving downstream utility.

By Yuxin Xiao, Sheng Zhang, Chandan Singh, Tristan Naumann, Hoifung Poon, Jianfeng Gao, Xiaodong Liu
arXiv Computer Vision
1d ago

From Image Interpretation to Clinical Reasoning: Upstream Physician-Context-Aware Multimodal Learning with Causal Reinforcement Learning

arXiv:2609.38924v1 Announce Type: new Abstract: Major adverse cardiovascular events (MACE) remain the leading cause of mortality worldwide. Opportunistic screening using routinely acquired clinical d...

By Jialu Pi, Yanan Ma, Weijie Chen, Owen Crystal, Shubham Trivedi, Stephen Xie, Anna Silverman, Matthew Stib, Chadi Ayoub, Reza Arsanjani, Imon Banerjee
arXiv AI
Jun 30

An AI agent for treatment reasoning over a biomedical tool universe

arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.

By Shanghua Gao, Ayush Noori, Richard Zhu, Curtis Ginder, Zhenglun Kong, Xiaorui Su, Justin Kauffman, Benjamin S. Glicksberg, Joshua Lampert, Ankit Sakhuja, Ashwin Sawant, ATHENA-R1 Evaluation Consortium, David A. Clifton, Noa Dagan, Ran Balicer, Marinka Zitnik
arXiv AI
Aug 25

Teaching LLMs How ICU Physicians Approach Clinical Reasoning Through OMOP-Aligned Retrieval Improves Reasoning Across Clinical Domains

arXiv:2608.22622v1 Announce Type: cross Abstract: Clinical decision-making relies on identifying relevant patient information to guide diagnosis and treatment, a challenge that is especially difficul...

By Miguel Contreras, Scott Siegel, Subhash Nerella, Jessica Sena, Jiaqing Zhang, Heng Sun, Hruday Tej Akkaladevi, Peiyu Lu, Jordan Rosen, Sumit Kapoor, Sasank Desaraju, Grace R. Thompson, Jacob Purcell, Michael Petrauskis, Philip KW. Hong, Meghan Brennan, Sarah Chrabaszcz, Tierra Smith, Ronnie Ren, Michel S. Kabbash, Ceyhun Haziroglu, Rushi Patel, Gabriel Gomez, Charlotte Chaiklin, Randy Leung, Kenneth N. John, Whitman Wiggins, Philip Kayser, Vincent Bird, Maria Bruzzone, Tyler J. Loftus, Azra Bihorac, Parisa Rashidi