RES-MR: Risk-Aware Reasoning for Explainable and Safe Medication Recommendation
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arXiv:2608. 03028v1 Announce Type: new Abstract: Applying a valid medication-safety rule when its patient-specific conditions are not met can produce an incorrect decision.
HEM-Med introduces a hierarchical agentic memory framework for safe multi‑center medication recommendation, addressing two key gaps in existing methods. It disentangles cross‑hospital clinical experience from hospital‑specific prescribing patterns via a hierarchical memory module, and incorporates a safety‑aware medication set generation module that considers drug‑drug interactions and local formulary constraints. Experiments on a real‑world multi‑center eICU dataset demonstrate that HEM‑Med outperforms representative transfer learning, LLM‑based, and MR baselines in both recommendation accuracy and safety.
HADRec is a Hierarchy-Aware Drug Recommendation framework that fuses molecular knowledge and electronic health records to improve medication recommendation. It uses LLaMA-7B to encode clinical notes, ChemBERTa to encode drug SMILES strings, and a cross‑attention mechanism for multimodal fusion, while a hierarchical predictor and consistency constraint loss enforce adherence to the ATC classification system. Experiments on MIMIC‑III and MIMIC‑IV show state‑of‑the‑art performance, strong generalization, and well‑calibrated predictions, with counterfactual evaluation indicating clinically aligned reasoning.
Medication recommendation (MR) is critical for clinical decision support. While existing MR methods are mostly designed for single-center learning, where only one independent hospital is involved, mul...
arXiv:2609.06779v1 Announce Type: cross Abstract: Drug repurposing aims to identify new therapeutic uses for existing compounds and, compared with de novo drug discovery, offers a faster and more cos...
The paper introduces BAR, a Budget‑Aware LLM Reasoning framework that enhances post‑discharge risk prediction by integrating external medical knowledge graphs (KGs). BAR refines KGs into disease‑specific evidence graphs with support scores and provenance, then uses an LLM to plan, navigate, and verify evidence within a patient‑specific budget. Experiments on MIMIC‑III and MIMIC‑IV across eight diseases show BAR improves AUPRC by 3.4 points, raises citation precision from 59.8% to 77.9%, and uses only 62‑65% of the allotted budget.