arXiv Computer Vision

Radiologist-Guided Causal Concept Bottleneck Models for Chest X-Ray Interpretation

arXiv AI
Sep 10

A radiographic world model for clinical reasoning and evidence generation

The paper introduces MedDream, a radiographic world model that learns a shared continuous latent state from paired chest radiograph-text observations. MedDream outperforms existing diagnostic and generative AI models across eight clinical datasets, improving diagnostic reasoning, resident concordance, and evidence generation. Targeted synthetic augmentation guided by subgroup performance gaps further enhances model performance, particularly for Asian patients.

By Suyang Xi, Songtao Hu, Shansong Wang, Mojtaba Safari, Luke del Balzo, Ehsan Ul Karim, Mingzhe Hu, Kuo Zhang, Tonghe Wang, Ralph R. Weichselbaum, Xiaofeng Yang
arXiv Machine Learning
Jul 30

Rethinking Clinical Relevance in Chest X-ray Machine Learning: How Evaluation References Define Performance

arXiv:2607. 26333v1 Announce Type: cross Abstract: Chest X-ray (CXR) machine learning relies heavily on automated evaluation using reference standards that aim to approximate clinical judgment.

By Panagiotis Fytas, Ian Selby, Clemens Karner, Judith Babar, Simon Baker, Jake Beckford, Timothy J. Sadler, Shahab Shahipasand, Arthikkaa Thavakumar, John Li Chen, Alex Sawer, Michael Roberts, Jonathan Weir-McCall, J. H. F. Rudd, Carola-Bibiane Sch\"onlieb, Anna Korhonen, Anna Breger
arXiv Machine Learning
Jun 5

Symb-xMIL: Symbolic Explanations for Multiple Instance Learning in Digital Pathology

arXiv:2606. 06224v1 Announce Type: cross Abstract: Explanations of multiple instance learning (MIL) models are widely used for validation and discovery in digital histopathology.

By Yanqing Luo (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Julius Hense (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Niklas Preni{\ss}l (Institute of Pathology, Charit\'e Universit\"atsmedizin, Berlin, Germany, Berlin Institute of Health at Charit\'e -- Universit\"atsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\'e Digital Clinician Scientist Program, Berlin, Germany), Andreas Mock (Institute of Pathology, Ludwig Maximilian University of Munich, Munich, Germany, Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany, NCT Heidelberg, Heidelberg, Germany, German Cancer Consortium), Klaus-Robert M\"uller (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany, Department of Artificial Intelligence, Korea University, Seoul, Korea, Max-Planck Institute for Informatics, Saarbr\"ucken, Germany), Thomas Schnake (Department of Chemistry, Chemical Physics Theory Group, University of Toronto, Canada, Vector Institute for Artificial Intelligence, Toronto, Canada, Acceleration Consortium, University of Toronto, Canada), Mina Jamshidi Idaji (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany)
arXiv Machine Learning
Aug 19

Pathology Transport: Optimal-Transport Explanations for Clinical Data, and When Their Heatmaps (Fail to) Localize Disease

The paper presents an optimal‑transport based generative model that learns the distributional differences between healthy and diseased patients, producing per‑patient counterfactuals and label‑free attribution heatmaps. On tabular breast cancer data the model achieves high malignancy scoring (AUROC ≈ 0.91) and its attributions correlate moderately with a supervised classifier, yet it does not surpass logistic regression. In chest X‑ray experiments the transport heatmaps capture population‑level signals but fail to localize real lesions, revealing a synthetic‑to‑real gap that challenges the reliability of label‑free explanations.

By Lalit Kumar
arXiv Machine Learning
Jun 5

A Vision-language Framework for Comparative Reasoning in Radiology

arXiv:2606. 06407v1 Announce Type: cross Abstract: Medical imaging artificial intelligence has achieved strong performance in isolated image interpretation, but remains poorly aligned with radiological practice, where diagnosis and follow-up rely on comparison across prior studies and analogous reference cases.

By Tengfei Zhang, Ziheng Zhao, Lisong Dai, Xiaoman Zhang, Pengcheng Qiu, Ya Zhang, Yanfeng Wang, Weidi Xie