arXiv Machine Learning

CLARITY: Medical World Model for Guiding Treatment Decisions by Modeling Context-Aware Disease Trajectories in Latent Space

arXiv:2512. 08029v3 Announce Type: replace Abstract: Clinical decision-making in oncology requires predicting dynamic disease evolution, a task current static AI predictors cannot perform.

arXiv AI
Jul 7

Graph Representation Learning of Longitudinal Medical Imaging Trajectories for Treatment Response Prediction

arXiv:2607. 04912v1 Announce Type: cross Abstract: In patients with breast cancer, pathological complete response (pCR) has been established as a clinically meaningful surrogate marker for long-term outcomes.

By Johannes Kiechle, Richard Osuala, Daniel M. Lang, Stefan M. Fischer, Ivana Jan\'i\v{c}kov\'a, Karim Lekadir, Julia A. Schnabel, Jan C. Peeken
arXiv AI
Jun 6

Towards World Models in Biomedical Research

arXiv:2606. 05925v1 Announce Type: new Abstract: A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention.

By Guangyu Wang, Jingkun Yue, Siqi Zhang, Yu Liu, Xiaoyu Wang, Mingyuan Meng, Changwei Ji, Zongbo Han, Yulin Wang, Yang Yue, Frank Fu, Ting Chen, Song Wu, Ziwei Liu, Jiangning Song, Ming Li, Gao Huang, Xiaohong Liu, Athanasios Vasilakos, Xingcai Zhang, Ping Zhang, Yong Li
Hugging Face Trending Papers
6d ago

Intervention-Aware Clinical World Model for Post-Op Outcome Forecasting in Cardiology

Many clinical prediction models treat post-intervention outcomes as a one-step mapping from baseline measurements to a future endpoint. However, recovery after a procedure often unfolds as an irregular trajectory: clinical observations, medication changes, repeat interventions, and physiological measurements are recorded asynchronously and can change risk assessment over time.

arXiv Machine Learning
Jun 2

MedGym:A Unified Continuous-Time Benchmark for Dynamic Medical Treatment Reinforcement Learning

arXiv:2606. 01028v1 Announce Type: new Abstract: Medical treatment recommendation poses several challenges to reinforcement learning (RL): patient physiology evolves in continuous time, measurements and interventions are performed at irregular intervals, and treatment effects vary substantially across individuals.

By Yuepeng Wang, Ken Kawano, Yongqi Zhou, Yoshihiko Fujisawa, Richard Weiss, Akifumi Wachi, Katsuki Fujisawa, Ying Chen, Mehrshad Sadria, Xin Liu, Kyoung-Sook Kim, Xiao Hu, Sebastien Gros, Xun Shen
arXiv Machine Learning
Aug 4

EHR2Path: Comprehensive Pathway-Level Modeling of Longitudinal Patient Trajectories from Multimodal Electronic Health Records

arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.

By Chantal Pellegrini, Ege \"Ozsoy, David Bani-Harouni, Matthias Keicher, Nassir Navab