arXiv AI

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

NOAH is a generative transformer that learns the full multimodal patient journey by integrating bidirectional time and a variational latent space. Trained on over 559 million clinical events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual intervention simulation, yielding strong performance on clinical outcomes, ICD chapters, comorbidities, and time‑to‑event prediction.

Hugging Face Trending Papers
5d ago

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

NOAH is a generative transformer that models the entire multimodal patient journey by integrating bidirectional time and a variational latent space to capture continuous, stochastic clinical trajectories. Trained on over 559 million events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual simulations, yielding strong predictive performance across 15 ICD chapters, 29 comorbidities, and time‑to‑event outcomes.

arXiv Machine Learning
Aug 19

Mr.Dec: Daily-Scale Longitudinal Multimodal Modeling for 30-Day Readmission Prediction

Mr.Dec is a new Transformer‑decoder model that predicts 30‑day hospital readmission by treating each admission as a chronological sequence of daily multimodal events, integrating Electronic Health Record updates and Chest X‑ray findings. It uses disease‑specific supervised contrastive learning to shape a diagnosis‑aware latent space and preserves day‑level clinical signals that other methods often compress. Experiments on MIMIC‑IV and MIMIC‑CXR datasets show state‑of‑the‑art performance and the model can highlight "Critical Days" for actionable real‑time risk stratification.

By Minjun Kim, Jong Hak Moon
arXiv Machine Learning
Jul 20

LLM4EHR: Aligning Clinical Time Series with Medical Event Sequences via Large Language Models

arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.

By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi
arXiv Machine Learning
Aug 4

EHR2Path: Comprehensive Pathway-Level Modeling of Longitudinal Patient Trajectories from Multimodal Electronic Health Records

arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.

By Chantal Pellegrini, Ege \"Ozsoy, David Bani-Harouni, Matthias Keicher, Nassir Navab
arXiv Machine Learning
Aug 19

MultiSigBERT: Beyond Survival Analysis through Multimodal and Sequential Modeling in Oncology

MultiSigBERT is a unified framework that performs multimodal sequential survival modeling in oncology by integrating narrative clinical reports, numerical measurements, and structured variables. The method converts free-text reports into sentence embeddings, compresses them with modality-specific PCA, and concatenates them with structured covariates to create joint temporal trajectories. These trajectories are encoded using the Signature transform from Rough Paths theory, and the resulting high-dimensional features are fed into a LASSO-regularized Cox model, achieving a concordance index of 0.743 on an independent test set of over 2,500 patients.

By Paul Minchella, St\'ephane Chr\'etien, Guillaume Metzler, Lo\"ic Verlingue, R\'emi Vaucher