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arXiv Machine Learning

MedGym:A Unified Continuous-Time Benchmark for Dynamic Medical Treatment Reinforcement Learning

arXiv:2606. 01028v1 Announce Type: new Abstract: Medical treatment recommendation poses several challenges to reinforcement learning (RL): patient physiology evolves in continuous time, measurements and interventions are performed at irregular intervals, and treatment effects vary substantially across individuals.

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arXiv Machine Learning
Sep 22

A Unified Benchmark for Dynamic Medical Treatment Reinforcement Learning

The paper introduces MedGym, a benchmark environment for dynamic medical treatment recommendation that models patient evolution in continuous time using Physics-Informed Neural Networks. It addresses gaps in existing reinforcement learning (RL) approaches by allowing evaluation of RL methods under irregular measurement intervals, personalized treatment responses, and safety considerations. MedGym enables direct comparison between discrete-time and continuous-time RL methods and supports clinically relevant metrics such as personalization and trajectory-level safety.

By Yuepeng Wang, Ken Kawano, Yoshihiko Fujisawa, Yongqi Zhou, Akifumi Wachi, Mehrshad Sadria, Lei Zhou, Richard Weiss, Katsuki Fujisawa, Ying Chen, Xin Liu, Kyoung-Sook Kim, Xiao Hu, Sebastien Gros, Xun Shen
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arXiv Machine Learning
Jun 2

Interaction-Limited Safe Continuous-Time RL for Dynamical Medical Treatment

arXiv:2606. 01051v1 Announce Type: new Abstract: Dynamic medical treatment requires deciding treatment intensity and intervention timing, while patient states evolve continuously and adverse events may occur between clinical interactions.

By Xun Shen, Yuepeng Wang, Akifumi Wachi, Yongqi Zhou, Richard Weiss, Yoshihiko Fujisawa, Ken Kawano, Mehrshad Sadria, Ying Chen, Xin Liu, Sebastien Gros, Xiao Hu, Kyoung-Sook Kim, Mengmou Li, Katsuki Fujisawa, Kenji Wakabayashi
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arXiv Machine Learning
Jul 21

Enhancing Personalized Bladder Cancer Treatment Through Reinforcement Learning: A Recurrent Patient State Transition Decision Support Framework

arXiv:2607. 16916v1 Announce Type: new Abstract: Bladder cancer treatment requires personalized and adaptive decision-making, particularly for recurrent disease, where treatment effectiveness changes across successive clinical episodes.

By Divyansh Chawla, Anshu Garg, Isshaan Singh
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arXiv Machine Learning
Sep 14

Reinforcement Learning over Patient Trajectories for Clinical Reasoning in EHR Foundation Models

The paper proposes a reinforcement learning (RL) fine‑tuning framework for electronic health record (EHR) foundation models, treating them as generative policies over patient trajectories. By framing clinical prediction tasks such as hospital readmission as event‑conditioned, time‑windowed reasoning problems and designing time‑aware, rollout‑sensitive rewards, the authors show that RL fine‑tuning consistently outperforms pre‑trained backbones and strong baselines. The approach enables smaller models to surpass larger pre‑trained models in data‑limited settings, induces positive transfer across tasks, and produces trajectories with stronger structural and semantic alignment to ground truth, improving downstream utility.

By Yuxin Xiao, Sheng Zhang, Chandan Singh, Tristan Naumann, Hoifung Poon, Jianfeng Gao, Xiaodong Liu
reinforcement-learningfine-tuningsafety
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