arXiv AI

A Pipeline for Generating Longitudinal Synthetic Clinical Notes Using Large Language Models

arXiv:2606. 26879v1 Announce Type: new Abstract: Synthetic data is increasingly used to enable the development and evaluation of AI systems in domains where access to real-world data is restricted.

arXiv Computation and Language
Sep 1

Privacy-Preserving Generation of Clinical Narratives from Medical Terminologies

The paper introduces Term2Note, a method for generating full-length clinical notes under differential privacy constraints. It separates content and form, conditioning note sections on medical terms and applying distinct DP protections to terms and notes, followed by a DP quality maximizer. Experiments show that the synthetic notes closely match real clinical notes in statistical properties, and models trained on them perform comparably to those trained on real data, outperforming existing DP text generation baselines.

By Yuping Wu, Viktor Schlegel, Warren Del-Pinto, Srinivasan Nandakumar, Iqra Zahid, Yidan Sun, Hai Li, Usama Farghaly Omar, Amirah Jasmine, Arun-Kumar Kaliya-Perumal, Chun Shen Tham, Gabriel Connors, Anil A Bharath, Goran Nenadic
arXiv AI
Jun 16

MedSynth: Realistic, Synthetic Medical Dialogue-Note Pairs

arXiv:2508. 01401v2 Announce Type: replace-cross Abstract: Physicians spend significant time documenting clinical encounters, a burden that contributes to professional burnout.

By Ahmad Rezaie Mianroodi, Amirali Rezaie, Niko Grisel Todorov, Nadine A. Friedrich, Maria P Mogollon, Alexander Hernandez-Tirado, Guillermo Lopez Garcia, Cyril Rakovski, Frank Rudzicz
arXiv Computation and Language
Sep 22

Knowledge Graph-Augmented Ambient AI for Clinical Note Generation

arXiv:2609.22239v1 Announce Type: new Abstract: Ambient AI is increasingly adopted in healthcare to automatically generate clinical notes from patient-clinician conversations, with the potential to s...

By Jakir Hossain, Yi-Fei Zhao, Hongjian Wang, Minmei Shih, Katie Leigh Mullen, Ahmad P. Tafti, Leming Zhou, Manoj Purohit, William Hogan, Jay Zeng, Elizabeth Skidmore, Yanshan Wang
arXiv Computation and Language
Sep 10

MedDeID enables locally governed clinical-text de-identification from real or synthetic training data

MedDeID is an on‑premises framework that combines in‑house annotation, synthetic‑note generation, model training, inference, pseudonymisation and evaluation to de‑identify clinical text. On a Dutch hospital benchmark, a hospital‑trained transformer detected 98.9 % of identifying text while redacting only 0.24 % of non‑identifier text; a synthetic‑only model achieved 96.1 %. In primary‑care notes, the synthetic‑trained model outperformed the hospital‑trained model in recall and robustness to identifier‑format changes, and an English version trained without real text reached 99.7 % and 98.9 % detection on synthetic benchmarks.

By Stig Hellemans, Tom Stroobants, Elyne Scheurwegs, Pieter Meysman, Philippe G. Jorens, Kris Laukens
arXiv Machine Learning
Jul 7

Memisis: Orchestrating and Evaluating Synthetic Data for Tabular Health Datasets

arXiv:2605. 17758v2 Announce Type: replace Abstract: Synthetic data is widely used in healthcare to create datasets that preserve statistical properties of real data without exposing sensitive patient information.

By Nitish Nagesh, Pengbao Zhou, Atchuth Naveen Chilaparasetti, Yajat Nagaraj Kiran, Tu Nguyen, Arshia Harish Puthran, Muhjaazee Love, Aadi Sharma, Mahdi Bagheri, Ian Harris, Amir M. Rahmani
arXiv Computation and Language
Aug 25

Clinically Grounded Privacy Evaluation of Medical LMs

The paper introduces a clinically grounded privacy evaluation framework for medical language models, assessing leakage across a spectrum of adversarial access levels—from publicly inferable demographics to leaked note fragments. Using this framework on an LM pretrained on 378,000 clinical notes, the authors find that routine encounter metadata leads to high verbatim memorization and significant recovery of sensitive diagnoses (e.g., AUROC 0.91 for abortion, 0.82 for HIV). They also note that exact-match memorization can overstate disclosure, with 36% of memorized tokens being templated documentation, underscoring the risks of training on longitudinal clinical data and offering a reusable evaluation tool.

By Sasha Ronaghi, Sana Tonekaboni, Lena Stempfle, Vivian Utti, Jordan Li Cahoon, Nathaniel Hendrix, Ayin Vala, Marzyeh Ghassemi, Emily Alsentzer
arXiv Computation and Language
Sep 1

CARE: Privacy-Compliant Agentic Reasoning with Evidence Discordance

The paper introduces MIMIC-DOS, a dataset derived from MIMIC-IV that focuses on ICU cases where patient symptoms and medical signs are discordant. It presents CARE, a privacy‑compliant multi‑stage agentic reasoning framework that uses a proprietary LLM to generate structured categories and transitions, while a local LLM performs evidence acquisition and decision‑making. In retrospective evaluations on MIMIC‑DOS, CARE outperforms other LLMs and agentic workflows, demonstrating stronger handling of conflicting clinical evidence while preserving patient privacy.

By Haochen Liu, Weien Li, Rui Song, Zeyu Li, Chun Jason Xue, Xiao-Yang Liu, Sam Nallaperuma-Herzberg, Xue Liu, Ye Yuan