arXiv Computer Vision

SkNeXt enables topology-guided neuronal reconstruction from petabyte-scale microscopy data

arXiv Computer Vision
Sep 21

Catena: A Comprehensive Software Suite for Large-Scale Connectomics

Catena is an open‑source, developer‑centric software suite designed to streamline large‑scale connectomics from electron microscopy data. It integrates modules for 3D neuron and organelle segmentation, synapse detection, microtubule tracking, and neurotransmitter inference into composable, chunk‑wise pipelines that are fully documented and extensible. The suite includes pretrained machine learning models, containerized runtimes, and shareable components to reduce compute and ground‑truth data needs while ensuring reproducible, scalable processing across workstations and clusters.

By Samia Mohinta, Pedro G\'omez-G\'alvez, Shi Yan Lee, Daniel Franco-Barranco, Michael Clayton, Stephan Preibisch, Jan Funke, Albert Cardona
arXiv AI
5d ago

Atelier: Learning Local Self-Supervised Features for CryoEM Volumes via Hypernetworks

Atelier is a self‑supervised framework that uses a transformer‑based hypernetwork to generate implicit neural representations (INRs) for cryo‑EM maps, enabling efficient, scale‑agnostic, coordinate‑conditioned feature extraction. Trained on 5,439 maps from the Electron Microscopy Data Bank, the pretrained INR provides continuous local feature fields that can be used as auxiliary channels for a 3D nested U‑Net, improving voxel‑level property prediction across eight tasks compared to a volume‑only baseline. The approach demonstrates that amortized INRs can serve as a geometry‑aware primitive for large‑scale cryo‑EM analysis.

By Phillip Lo, Sudarshan Babu, Dari Kimanius, Aly A. Khan
arXiv Computer Vision
Sep 23

Uncertainty-Aware 3D Residual Wavelet Diffusion for Ultra Low-Field MRI Super-Resolution

The paper introduces a 3D residual wavelet diffusion model for super‑resolving ultra low‑field MRI scans. By using a lossless wavelet reparameterisation, residual shifting, and domain randomisation, the method fits whole‑brain data on a single GPU, speeds up sampling, and generalises across scanners. It achieves volumetric accuracy comparable to leading regression approaches while producing per‑voxel uncertainty maps that reveal under‑determined regions and preserves disease‑relevant atrophy in cognitively impaired subjects.

By Rui W. Yeow, Millie Beament, Fred Dick, Raha Razin, Martina Bocchetta, David L. Thomas, Henry F. J. Tregidgo, Daniel C. Alexander, James H. Cole
arXiv Computer Vision
Sep 10

Advanced Brain Tissue Imaging with Data-Consistent Diffusion Priors in Laminographic X-Ray Nanoimaging

arXiv:2609.10456v1 Announce Type: new Abstract: Nanoscale imaging of mammalian brains is critical for connectomics. X-ray laminography enables high-throughput imaging of extended, plate-like biologic...

By Wenxuan Fang, Abraham L. Levitan, Ana Diaz, Carles Bosch, Adrian Wanner, Andreas T. Schaefer, Mirko Holler, Tomas Aidukas, Nicholas W. Phillips, Yuxin Zhang, Alexandra Pacureanu, Manuel Guizar-Sicairos, Luis Barba
arXiv Machine Learning
Aug 11

Beyond Isotropic Assumptions: Continuity-Constrained Segmentation and GPU Morphometry for Nanoscale GBM Analysis

arXiv:2608. 07575v1 Announce Type: cross Abstract: Confocal microscopy of optically cleared and swelled tissue resolves complex biological structures in 3D, but such acquisitions are highly anisotropic: along the under-sampled axial direction the structure can appear discontinuous, hampering reconstruction and automated quantitative analysis.

By Arash Fatehi, Robin Ebbestad, Linus Butt, Hans Blom, Sigrid Lundberg, Hannes Olauson, Hjalmar Brismar, David Unnersj\"o-Jess, Thomas Benzing, Katarzyna Bozek
arXiv Computer Vision
Sep 2

Prior-Guided Implicit Neural Representations for Single-Subject Diffusion MRI Super-Resolution

The paper introduces a transfer‑learning framework that pre‑trains an implicit neural representation (INR) on a high‑resolution diffusion MRI template and then adapts it to individual subjects through registration and fine‑tuning. This approach enables native single‑subject super‑resolution, achieving a 4× through‑plane up‑sampling from 5 mm to 1.25 mm on Human Connectome Project data. Compared to a recent baseline, the method reduces NRMSE by 36–49 % and increases FSIM by 24–43 %, while training 6× faster and outperforming other INR‑based techniques on both image quality and domain‑specific metrics.

By Abdulkader Ghandoura, Marsil Zakour, William Consagra, Yogesh Rathi