The study investigates whether pathology foundation models can enable training‑free, content‑based retrieval of similar cases from digitized archives of salivary gland tumors. Using a region of interest from a whole slide image, the models retrieve morphologically similar cases and their ICD‑O codes without task‑specific training. Evaluation on 137 cases across 12 morphology categories shows that Atlas2 achieves the highest retrieval accuracy, with macro‑averaged F1 scores ranging from 69.0% to 76.6% across models.
By Maximilian J. Roesel, Niklas Kiermeyer, Philipp Keyl, Frederick Klauschen
arXiv:2610.14226v1 Announce Type: cross
Abstract: Purpose : To develop and evaluate CAPTOR, a deep-learning vision-language foundation model for oncologic chest-abdomen-pelvis (CAP) CT interpretation...
By S\'el\'ena Jean-Mactoux, Sophie Loizillon, Ghina Jardali, Amandine Cromb\'e, Nathalie Lassau, Alexandre B\^one
WILSON is a vision–language foundation model that represents whole‑slide images and multi‑slide patient cases as single multi‑magnification composite images. Trained on about 189,000 Mayo Clinic slides covering 42 organs and 829 diagnostic entities, it outperforms dedicated case‑level models on internal cohorts and matches slide‑level models while using far less compute. Fine‑tuning on triple‑negative breast cancer data improves histologic subtyping and lymphocyte grading, and the model retrieves diagnostic text with high recall and generates captions closer to report references than prior methods.
By Saghir Alfasly, Wataru Uegami, Sobhan Hemati, Wenchao Han, Xiaojia Tang, Kevin Thompson, Daniel Stone, Ghazal Alabtah, Saba Yasir, Michael R. Lucas, Eric W. Klee, Cheryl L. Willman, Judy C. Boughey, Matthew P. Goetz, Krishna R. Kalari, H. R. Tizhoosh
arXiv:2605. 24253v2 Announce Type: replace-cross Abstract: Digital pathology archives increasingly contain multiple whole-slide images (WSIs) per case, capturing spatially distinct tumour regions and reflecting intrinsic morphological heterogeneity.
By Zahra Rahimi Afzal, Wataru Uegami, Saghir Alfasly, Saba Yasir, Judy C. Boughey, Matthew P. Goetz, Krishna R. Kalari, H. R. Tizhoosh
arXiv:2510.23224v2 Announce Type: replace
Abstract: The rapid digitization of histopathology slides has opened new opportunities for computational tools in clinical and research workflows. Content-ba...
By Hongyi Wang, Zhengjie Zhu, Junlin Hou, Jiabo Ma, Fang Wang, Yue Shi, Qiuyu Cai, Jili Wang, Bo Luo, Zhizhong Chai, Zhengyu Zhang, Li Liang, Xiuming Zhang, Yen-Wei Chen, Lanfen Lin, Hao Chen
arXiv:2609.32876v2 Announce Type: replace-cross
Abstract: State-of-the-art pathology foundation models, trained on millions of histology tiles, can fail to preserve tissue similarity when comparisons...
By Yishu Zhang, Yun Li, Daiwei Zhang
arXiv:2606. 07368v1 Announce Type: cross Abstract: Automated mitosis detection is a well-established task in computational pathology.
By Marc Aubreville, Jonas Ammeling, Sweta Banerjee, Viktoria Weiss, Taryn A. Donovan, Robert Klopfleisch, Jiaqi Lv, Shan E Ahmed Raza, Rapha\"el Bourgade, Thomas Walter, Yasemin Topuz, Song\"ul Varl{\i}, Charles-Antoine Collins-Fekete, Zhuoyan Shen, Navya Sri Kelam, Nitin Singhal, Christian Marzahl, Brian Napora, Tengyou Xu, Hongyan Gu, Mario Vento, Gennaro Percannella, Norbert Ropiak, Izabela Wasiak, Jie Xiao, Shaojun Liu, Seungho Choe, April Khademi, Vidushi Walia, Sujatha Kotte, Andrew Broad, Alex Wright, Guillaume Balezo, Esha Sadia Nasir, Mostafa Jahanifar, Yosuke Yamagishi, Shouhei Hanaoka, Mattia Sarno, Francesco Tortorella, Biwen Meng, Jingxin Liu, Sara Krauss, Daniel Hieber, Lavish Ramchandani, Dev Kumar Das, Mieko Ochi, Yuan Bae, Piotr Giedziun, Mateusz Maniewski, Vangala Govindakrishnan Saipradeep, Naveen Sivadasan, Leire Benito-Del-Valle, Adrian Galdran, Kaustubh Atey, Sameer Anand Jha, Adinath Dukre, Imran Razzak, Maxime W. Lafarge, Viktor H. Koelzer, Nils Porsche, Nikolas Stathonikos, Mitko Veta, Dominik Hirling, Zsanett Zs\'ofia Iv\'an, Peter Horvath, Katharina Breininger, Christof A. Bertram
We describe the DS@GT submissions to the ImageCLEFmedical Caption 2026 challenge, which continues a long-running benchmark on the ROCOv2 dataset with two tracks: Concept Detection (Task 1), assigning UMLS Concept Unique Identifiers (CUIs) to radiology images, and Caption Prediction (Task 2), generating natural-language captions. For Task 1, our primary submission was a three-way late-fusion ensemble of ConvNeXt-V2, BiomedCLIP ViT-B/16, and DenseNet-169 with a regularized ''Honest Threshold Tuning'' procedure designed to avoid validation overfitting on rare concepts; this submission ranked first on the official submission with a primary $F_1$ of $0.
arXiv:2608. 02615v1 Announce Type: cross Abstract: Cancer diagnosis and characterization require integrating complementary evidence from radiology, pathology, genomics, and clinical metadata.
By Ahnaf Munir, Dannong Wang, Michael W. McDonald, Mubarak Shah, Pegah Khosravi, Yu Tian
arXiv:2607. 27763v1 Announce Type: cross Abstract: We describe the DS@GT submissions to the ImageCLEFmedical Caption 2026 challenge, which continues a long-running benchmark on the ROCOv2 dataset with two tracks: Concept Detection (Task 1), assigning UMLS Concept Unique Identifiers (CUIs) to radiology images, and Caption Prediction (Task 2), generating natural-language captions.
By Bowen Wang, Youwen Zhang, Ritesh Mehta
HERO (Histology Encoder for Robust Representation in Oncology) is a ViT‑G/14 pathology foundation model trained with DINO and iBOT objectives and refined using high‑resolution Gram anchoring on a 500‑million‑tile corpus from about 575,000 clinical whole‑slide images. It demonstrates superior robustness to center, scanner, and stain variation compared to other state‑of‑the‑art foundation models, while maintaining competitive performance on tile‑level classification, segmentation, and gene‑expression prediction. Across 39 slide‑level clinical tasks, HERO ranks first on average and achieves the best average rank across six benchmark frameworks under an equal‑weighted analysis.
By Zhi Li (Caris Life Sciences, Irving, TX, United States), Eghbal Amidi (Caris Life Sciences, Irving, TX, United States), Yating Cheng (Caris Life Sciences, Irving, TX, United States), Tyson Dawson (Caris Life Sciences, Irving, TX, United States), Gorkem Can Ates (Caris Life Sciences, Irving, TX, United States), Shuzhen Kuang (Caris Life Sciences, Irving, TX, United States), Norsang Lama (Caris Life Sciences, Irving, TX, United States), Md Ashequr Rahman (Caris Life Sciences, Irving, TX, United States), Zhiying Lu (Caris Life Sciences, Irving, TX, United States), Elisabeth K. Kong (Caris Life Sciences, Irving, TX, United States), Milan Radovich (Caris Life Sciences, Irving, TX, United States), David Spetzler (Caris Life Sciences, Irving, TX, United States), Matthew Oberley (Caris Life Sciences, Irving, TX, United States), George W. Sledge (Caris Life Sciences, Irving, TX, United States), Ming Chen (Caris Life Sciences, Irving, TX, United States)
arXiv:2606. 12346v1 Announce Type: cross Abstract: Hematoxylin and eosin (H&E) staining is the cornerstone of histopathology, yet scalable, quantitative analysis of H&E whole-slide images (WSIs) remains a central challenge in computational pathology.
By Kai Standvoss, Miriam H\"agele, Rosemarie Krupar, Julika Ribbat-Idel, Jennifer Altsch\"uler, Gerrit Erdmann, Hans Pinckaers, Evelyn Ramberger, Madleen Drinkwitz, \'Ad\'am N\'arai, Alexander M\"ollers, Katja Lingelbach, Sebastian Kons, Lukas H\"onig, Recepcan Adig\"uzel, Joana Bai\~ao, Alberto Megina Gonzalo, Marius Teodorescu, Marie-Lisa Eich, Paolo Chetta, Shakil Merchant, Verena Aumiller, Simon Schallenberg, Andrew Norgan, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen