arXiv AI

CRISP -- Clustering-Based Redundancy-Reduced Instance Sampling for Pathology Case Representation and Retrieval

arXiv:2605. 24253v2 Announce Type: replace-cross Abstract: Digital pathology archives increasingly contain multiple whole-slide images (WSIs) per case, capturing spatially distinct tumour regions and reflecting intrinsic morphological heterogeneity.

arXiv Machine Learning
Sep 23

WILSON - a pathology foundation model framework for patient-level analysis and diagnostic text generation

WILSON is a vision–language foundation model that represents whole‑slide images and multi‑slide patient cases as single multi‑magnification composite images. Trained on about 189,000 Mayo Clinic slides covering 42 organs and 829 diagnostic entities, it outperforms dedicated case‑level models on internal cohorts and matches slide‑level models while using far less compute. Fine‑tuning on triple‑negative breast cancer data improves histologic subtyping and lymphocyte grading, and the model retrieves diagnostic text with high recall and generates captions closer to report references than prior methods.

By Saghir Alfasly, Wataru Uegami, Sobhan Hemati, Wenchao Han, Xiaojia Tang, Kevin Thompson, Daniel Stone, Ghazal Alabtah, Saba Yasir, Michael R. Lucas, Eric W. Klee, Cheryl L. Willman, Judy C. Boughey, Matthew P. Goetz, Krishna R. Kalari, H. R. Tizhoosh
arXiv Computer Vision
Sep 15

Accurate and Scalable Multimodal Pathology Retrieval via Attentive Vision-Language Alignment

arXiv:2510.23224v2 Announce Type: replace Abstract: The rapid digitization of histopathology slides has opened new opportunities for computational tools in clinical and research workflows. Content-ba...

By Hongyi Wang, Zhengjie Zhu, Junlin Hou, Jiabo Ma, Fang Wang, Yue Shi, Qiuyu Cai, Jili Wang, Bo Luo, Zhizhong Chai, Zhengyu Zhang, Li Liang, Xiuming Zhang, Yen-Wei Chen, Lanfen Lin, Hao Chen
arXiv Computer Vision
Sep 10

Synergistic Vision-Language Reinforcement Enables Scalable On-Demand Analysis across Diverse Clinical Tasks

arXiv:2505.03380v2 Announce Type: replace Abstract: Accurate delineation of tumors and surrounding organs-at-risk is essential for radiotherapy, surgery and treatment response assessment, yet remains...

By Haonan Wang, Jiaji Mao, Lehan Wang, Qixiang Zhang, Marawan Elbatel, Yi Qin, Huijun Hu, Baoxun Li, Wenhui Deng, Weifeng Qin, Hongrui Li, Jialin Liang, Jun Shen, Xiaomeng Li
Hugging Face Trending Papers
Jul 21

PathAgentBench: Benchmarking Evidence-Seeking Vision-Language Models on Whole-Slide Pathology Image

Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating multi-scale evidence. However, most existing pathology benchmarks evaluate models on pre-cropped patches or pre-extracted slide features, leaving their ability to acquire evidence directly from gigapixel WSIs largely untested.

arXiv Machine Learning
Sep 3

Morphology signal in whole slide image foundation models can automatically triage slides

The paper introduces a pipeline that uses publicly available whole slide image foundation models (FMs) to automatically triage slides by ranking them based on zero‑shot classification predictions. This approach accurately identifies slides containing the most tumor, achieving top‑2 ranking for patients with up to 43 slides across multiple datasets. The study also proposes a ranked evaluation framework to benchmark FM performance in slide triage.

By Ayushi Sinha, Shashank Yadav, Benjamin Holmes, Pravat Das, Aaron W. Bogan, James S. Lewis Jr., Santiago Romero-Brufau, Andrew Y. K. Foong, Scott H. Kaufmann, Kathryn M. Van Abel, David M. Routman, Michael R. Lucas
arXiv AI
Jun 30

Data-Efficient Multimodal Alignment for Histopathology-based Molecular Prediction

arXiv:2606. 29949v1 Announce Type: cross Abstract: H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability.

By Dominik Winter, Dominik Vonficht, Lo\"ic Le Bescond, Christian Gebbe, Marco Rosati, Richard J. Chen, Markus Schick, Ross Stewart, Nicolas Brieu
arXiv AI
Jul 22

PathAgentBench: Benchmarking Evidence-Seeking Vision-Language Models on Whole-Slide Pathology Image

arXiv:2607. 19261v1 Announce Type: cross Abstract: Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating multi-scale evidence.

By Dankai Liao, Tianyi Zhang, Yufeng Wu, Xinyue Zhang, Qiaochu Xue, Zeyu Liu, Dachun Zhao, Linghan Cai, Yueming Jin
arXiv AI
Aug 26

EviPathBench: Benchmarking Evidence Acquisition and Reasoning in Vision-Language Models for Whole-Slide Pathology

arXiv:2607.19261v4 Announce Type: replace-cross Abstract: Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating...

By Dankai Liao, Tianyi Zhang, Yufeng Wu, Xinyue Zhang, Qiaochu Xue, Zeyu Liu, Dachun Zhao, Linghan Cai, Yueming Jin