arXiv Machine Learning

SMILE: Self-Explainable Multimodal Information Bottleneck for Medical Diagnosis

The paper introduces SMILE, a self‑explainable multimodal information bottleneck framework for medical diagnosis. It jointly optimizes predictive accuracy and modality‑specific explainability by selecting the most informative elements within each data modality. Experiments on diverse medical datasets show strong diagnostic performance, including a 9.1‑percentage‑point accuracy gain on the iCTCF dataset, and provide transparent, modality‑aware explanations that enhance both explainability and generalization.

arXiv AI
Aug 21

MKG-CARE: Case-Aware Reasoning with Multimodal Knowledge Graphs for Explainable Medical Image Diagnosis

arXiv:2605. 22547v3 Announce Type: replace-cross Abstract: Medical image diagnosis has achieved significant progress with deep learning, yet existing methods often rely on isolated visual evidence and lack the ability to effectively leverage similar cases and external knowledge.

By Yiming Xu, Yixuan Liu, Yuhang Zhang, Ling Zheng, Yihan Wang, Qi Song
arXiv Machine Learning
Oct 2

Data-Driven Priors for Uncertainty-Aware Risk Prediction of Clinical Deterioration using Multimodal Data

The paper introduces MedCertAIn, a framework that uses data‑driven priors to enhance uncertainty estimation in multimodal clinical models. By integrating cross‑modal similarity and modality‑specific corruptions into neural network priors, the authors improve predictive performance and selective prediction for in‑hospital mortality risk using MIMIC‑IV and MIMIC‑CXR data. The results demonstrate competitive accuracy and notable gains over deterministic and stochastic baselines, underscoring the potential of such priors for reliable, uncertainty‑aware clinical decision support.

By L. Juli\'an Lechuga L\'opez, Tim G. J. Rudner, Farah E. Shamout
arXiv AI
Jul 29

Evaluating Multi-Turn Multimodal Diagnostic Reasoning on Challenging Real-World Clinical Cases

arXiv:2607. 25933v1 Announce Type: cross Abstract: Clinical diagnostic evaluation should not only assess whether models can provide correct diagnoses, but also reflect the realities of clinical practice, including progressive disclosure of multimodal information, dynamic updating of diagnostic hypotheses, and continuous refinement of clinical reasoning.

By Rui Yang, Weihao Xuan, Yi Lin, Zhuhan Bao, Jonathan Chong Kai Liew, Matthew Yu Heng Wong, Nicol\'as Lescano, Nikita R. Paripati, Emily Ling-Lin Pai, Jiarui Liu, Heli Qi, Heng-Jui Chang, Benny Kai Guo Loo, Huitao Li, Kunyu Yu, Yufan Wang, Chuan Hong, Shijian Lu, Douglas Teodoro, Naoto Yokoya, Ross Koppel, Mona Diab, Hua Xu, David W. Bates, Nan Liu, Yifan Peng
arXiv Machine Learning
Jul 7

OC-Distill: Ontology-aware Contrastive Learning with Cross-Modal Distillation for ICU Risk Prediction

arXiv:2604. 16878v2 Announce Type: replace Abstract: Early prediction of severe clinical deterioration and remaining length of stay can enable timely intervention and better resource allocation in high-acuity settings such as the ICU.

By Zhongyuan Liang, Junhyung Jo, Hyang-Jung Lee, Sang Kyu Kim, Irene Y. Chen
arXiv AI
Jul 20

Perception-Aligned AI Outputs: End-to-End Visual Prediction for Uncertainty Communication in Clinical Decision-Making

arXiv:2205. 04599v2 Announce Type: replace-cross Abstract: Explainable Artificial Intelligence (XAI) is essential for trustworthy AI in healthcare, yet many existing methods rely on technical explanations that are difficult for clinicians and patients to interpret.

By Mohammad Eslami, Solale Tabarestani, Saber Kazeminasab, Ehsan Adeli, Glyn Elwyn, Tobias Elze, Mengyu Wang, Nazlee Zebardast, Lucia Sobrin, Nassir Navab, Daniel Shu Wei Ting, Malek Adjouadi
arXiv Computation and Language
Aug 21

Explainable Multimodal Depression Recognition in Clinical Interviews via PHQ-Aligned Symptom Summarization

arXiv:2501. 16106v2 Announce Type: replace Abstract: Recent advances in multimodal depression recognition for clinical interviews (MDRC) have demonstrated the potential of AI systems by integrating textual, acoustic, and facial cues.

By Wenjie Zheng, Qiming Xie, Jianfei Yu, Yang Wang, Lei Cao, Fei Wang, Shijin Wang, Rui Xia, Chengqing Zong
arXiv AI
Oct 2

A Comparative Explainability Framework for DeBERTa-v3 in Zero-Shot Medical Abstract Classification

The paper introduces a comparative explainability framework for auditing DeBERTa‑v3 in zero‑shot medical abstract classification. It evaluates five explanation methods—SHAP, LIME, occlusion, Input × Gradient, and Attention × Gradient—using a natural language inference engine on a balanced corpus of 1,000 abstracts per diagnostic category. The study finds that explanatory stability aligns with predictive certainty, identifies three systemic failure mechanisms, and recommends combining multiple explanation methods and quantitative agreement metrics for transformer‑based medical text classifiers.

By Javier Diaz Esteban-Herreros, David Mu\~noz-Valero, Raquel Mart\'inez-Espa\~na, Jose M. Juarez, Juan Moreno-Garcia