The paper introduces egRUE, an explainable uncertainty estimation method that merges uncertainty quantification with feature‑level explanations for medical AI predictions. egRUE incorporates prediction explanations into its uncertainty calculation and decomposes uncertainty into contributions from individual features. Experiments and a user study with medical experts show that egRUE improves reliability, interpretability, and calibrated trust compared to existing methods.
By Li Rong Wang, Jamie Duell, Xinran Xu, Thomas C. Henderson, Yu Yue Hew, Pik Wan Erica Chiang, Xiao Wei Alstar Ang, Bingwen Eugene Fan, Xiuyi Fan
arXiv:2607. 24730v1 Announce Type: cross Abstract: Computer vision models have become highly effective for medical applications, yet their black-box nature continues to undermine clinician trust.
By Krithi Shailya, Ananya Lakshmi Ravi, Venkatanathan K. V., Sowmya S. Sundaram, Gokul S. Krishnan, Aditi Anand, Balaraman Ravindran
arXiv:2605. 28215v2 Announce Type: replace Abstract: In-context learning (ICL) enables multimodal large language models (MLLMs) to classify images from a few labelled examples.
By Carmen Quiles-Ram\'irez, Leticia L. Rodr\'iguez, Nicol\'as Martorell, Natalia D\'iaz-Rodr\'iguez
arXiv:2607. 29614v1 Announce Type: cross Abstract: The rapid adoption of deep learning models in high-risk domains has intensified the need for trustworthy Explainable Artificial Intelligence (XAI).
By Christian Oliva, Luis F. Lago-Fern\'andez
The paper introduces SMILE, a self‑explainable multimodal information bottleneck framework for medical diagnosis. It jointly optimizes predictive accuracy and modality‑specific explainability by selecting the most informative elements within each data modality. Experiments on diverse medical datasets show strong diagnostic performance, including a 9.1‑percentage‑point accuracy gain on the iCTCF dataset, and provide transparent, modality‑aware explanations that enhance both explainability and generalization.
By Yuqing Yang, Alexander Schmatz, Zhaozhao Ma, Changkyu Choi, Robert Jenssen, Shujian Yu
arXiv:2608. 07522v1 Announce Type: cross Abstract: We present a structured review of commonly used Explainable machine learning (XML) methodologies, including global and local interpretability tools such as SHapley Additive exPlanations (SHAP), Local Interpretable Model-Agnostic Explanations (LIME), Partial Dependence Plots (PDP), and Individual Conditional Expectation (ICE) plots.
By Krishna Padmanabhan, Minxin Lu, Dai Feng, Natalia KanDobrosky, Sai Konduri, Heather J. Litman, Achilleas Livieratos
MedVA is an end‑to‑end neuro‑symbolic agentic system designed to streamline medical volume visualization. It combines a neuro‑symbolic intent formulation agent that refines natural‑language requests with symbolic reasoning, a multi‑model ROI identification agent that uses pretrained medical segmentation models to locate specified regions, and an objective‑driven visualization optimization agent that evaluates ROI visibility using a volume‑based objective. Extensive evaluations and a formative user study demonstrate the system’s effectiveness and high usability across users with varying expertise.
By Haill An, Suhyeon Kim, Minjun Kang, Eunwoo Lee, Bin Sheng, Lei Bi, Younhyun Jung
The paper introduces a comparative explainability framework for auditing DeBERTa‑v3 in zero‑shot medical abstract classification. It evaluates five explanation methods—SHAP, LIME, occlusion, Input × Gradient, and Attention × Gradient—using a natural language inference engine on a balanced corpus of 1,000 abstracts per diagnostic category. The study finds that explanatory stability aligns with predictive certainty, identifies three systemic failure mechanisms, and recommends combining multiple explanation methods and quantitative agreement metrics for transformer‑based medical text classifiers.
By Javier Diaz Esteban-Herreros, David Mu\~noz-Valero, Raquel Mart\'inez-Espa\~na, Jose M. Juarez, Juan Moreno-Garcia
arXiv:2609.14823v1 Announce Type: new
Abstract: Multimodal clinical decision-making requires reliable reasoning over heterogeneous evidence from electronic health records, medical images, and physiol...
By Ji Lu, Lifei Liu, Haoran Yu, Xianglong Wang, Yiru Fang, Kuo Yang, Huiran Duan, Jianping Gou
arXiv:2606. 07180v1 Announce Type: cross Abstract: The growing demand for transparency in automated decision-making has propelled eXplainable Artificial Intelligence (XAI) to the forefront of machine learning research.
By Arthur Hoarau, Chenrui Zhu, Vu Linh Nguyen
arXiv:2512.13742v3 Announce Type: replace-cross
Abstract: Medical image classifiers detect gastrointestinal diseases well, but they do not explain their decisions. Large language models can generate...
By Md. Najib Hasan (Wichita State University, USA), Imran Ahmad (Wichita State University, USA), Sourav Basak Shuvo (Khulna University of Engineering and Technology, Bangladesh), Md. Mahadi Hasan Ankon (Khulna University of Engineering and Technology, Bangladesh), Nazmul Siddique (Ulster University, UK), Hui Wang (Queen's University Belfast, UK)
arXiv:2609.15180v1 Announce Type: new
Abstract: Vision-language models are increasingly explored for clinical prediction from electronic health records and medical images, where identifying unreliabl...
By Mingcheng Zhu, Jinning Liang, Tingting Zhu