arXiv Machine Learning

PatTree: a novel approach for automated creation of multimodal, graph-based patient representations for medical classification tasks

arXiv:2608. 02692v1 Announce Type: new Abstract: Access to holistic, multimodal data improves the performance of Artificial Intelligence (AI) in medical classification tasks compared to utilizing single modalities or data sources.

arXiv AI
Aug 21

MKG-CARE: Case-Aware Reasoning with Multimodal Knowledge Graphs for Explainable Medical Image Diagnosis

arXiv:2605. 22547v3 Announce Type: replace-cross Abstract: Medical image diagnosis has achieved significant progress with deep learning, yet existing methods often rely on isolated visual evidence and lack the ability to effectively leverage similar cases and external knowledge.

By Yiming Xu, Yixuan Liu, Yuhang Zhang, Ling Zheng, Yihan Wang, Qi Song
arXiv AI
Aug 28

Methodological and Conceptual Framework for 5D Multi-Table Analysis: A Unified Approach for Complex Data Reuse

The paper introduces the Relational Hypergraph Transformer (RHT), a unified architecture that models relational databases as hypergraphs and learns pentadimensional embeddings (PentE). RHT applies sparse relational attention whose complexity scales with the average relational degree, making it computationally efficient for large, high‑dimensional, and high‑cardinality datasets. Experiments on the Synthea synthetic electronic health record dataset show that RHT produces more semantically coherent embeddings than tabular, relational, and temporal graph baselines, while remaining scalable, and the authors provide an open‑source implementation and plan clinical validation on MIMIC‑IV.

By Edouard Lansiaux, Hugo Kazzi, Aur\'elien Loison, Slim Hammadi, Emmanuel Chazard
arXiv AI
Sep 17

Rethinking How We Evaluate Methodological Progress in Health AI

The study re‑implements 12 AI algorithms for electronic health records within a unified framework and evaluates them on MIMIC‑IV and NWICU datasets. It compares expert‑authored clinically meaningful tasks with randomly generated tasks, finding that pairwise algorithm comparisons transfer well across task families and datasets, yet clinically meaningful tasks show stronger task‑method interactions. The results also reveal that newer algorithms do not consistently outperform older ones, with gradient‑boosted trees remaining highly competitive when combined with modern EHR representations.

By Florent Pollet, Matthew McDermott
arXiv Machine Learning
Jul 28

Dementia Etiology Diagnosis via Collaborative Meta Knowledge Enhancement

arXiv:2607. 22770v1 Announce Type: new Abstract: Although artificial intelligence (AI) has shown promising performance in several medical tasks, accurate dementia etiology diagnosis with AI remains challenging due to complex overlapping symptoms among diseases.

By Siyuan Du, Mengxi Chen, Xinyang Jiang, Zilong Wang, Jiangchao Yao, Dongsheng Li, Ya Zhang, Lili Qiu, Yanfeng Wang
arXiv Machine Learning
Sep 7

SMILE: Self-Explainable Multimodal Information Bottleneck for Medical Diagnosis

The paper introduces SMILE, a self‑explainable multimodal information bottleneck framework for medical diagnosis. It jointly optimizes predictive accuracy and modality‑specific explainability by selecting the most informative elements within each data modality. Experiments on diverse medical datasets show strong diagnostic performance, including a 9.1‑percentage‑point accuracy gain on the iCTCF dataset, and provide transparent, modality‑aware explanations that enhance both explainability and generalization.

By Yuqing Yang, Alexander Schmatz, Zhaozhao Ma, Changkyu Choi, Robert Jenssen, Shujian Yu
arXiv AI
Sep 3

Unifying biomedical knowledge in a modern multimodal graph

OptimusKG is a multimodal biomedical labeled property graph that integrates structured and semi‑structured resources to preserve detailed, type‑specific metadata across molecular, anatomical, clinical, and environmental domains. The graph contains nearly 191,000 nodes, over 21.8 million edges, and more than 67 million property instances derived from 18 ontologies, with a top‑level schema that enforces node and edge constraints while retaining granular provenance. Validation using the PaperQA3 agent found that 70.0% of sampled edges are supported by literature evidence, and the graph offers a standardized resource for machine learning, knowledge‑grounded retrieval, and hypothesis generation in biomedical research.

By Lucas Vittor, Ayush Noori, I\~naki Arango, Joaqu\'in Polonuer, Sam Rodriques, Andrew White, David A. Clifton, Marinka Zitnik
arXiv AI
Jun 19

MedRLM: Recursive Multimodal Health Intelligence for Long-Context Clinical Reasoning, Sensor-Guided Screening, Evidence-Grounded Decision Support, and Community-to-Tertiary Referral Optimization

arXiv:2606. 20164v1 Announce Type: cross Abstract: Real-world clinical decision support requires reasoning over heterogeneous and longitudinal patient information rather than answering isolated medical questions.

By Aueaphum Aueawatthanaphisut
arXiv Machine Learning
Jul 14

Imputation-free transformer learning enables robust Alzheimer's disease prediction and calibrated uncertainty quantification across heterogeneous clinical cohorts

arXiv:2607. 11656v1 Announce Type: cross Abstract: Accurate diagnostic classification and disease-severity prediction for Alzheimer's disease are hampered by the incompleteness and heterogeneity of real-world clinical data.

By Christelle Schneuwly Diaz, Narmina Baghirova, Duy-Thanh Vu, Duy-Cat Can, Gilles Allali, Philippe Ryvlin, Oliver Y. Ch\'en