arXiv Machine Learning

Data-Driven Priors for Uncertainty-Aware Risk Prediction of Clinical Deterioration using Multimodal Data

arXiv Computer Vision
Sep 7

Real-World Multi-Modal and Longitudinal Lung Cancer Dataset

The paper presents a newly curated, multi-center, multi-modal, and longitudinal lung cancer dataset comprising 1,365 patients with whole-slide images, CT scans, PET scans, structured clinical data, transcriptomics, and follow-up information. The dataset features substantial, non-uniform missingness across modalities, making it ideal for evaluating robust multi-modal fusion strategies. Benchmarks on 12‑month overall survival, disease‑specific survival, and longitudinal hazard prediction demonstrate that integrating complementary modalities consistently outperforms uni-modal approaches, even under severe missing data.

By Rita Cordeiro Mendes, Maria Rita Fonseca Verdelho, Carlos Santiago, Catarina Barata
arXiv Machine Learning
Aug 19

Mr.Dec: Daily-Scale Longitudinal Multimodal Modeling for 30-Day Readmission Prediction

Mr.Dec is a new Transformer‑decoder model that predicts 30‑day hospital readmission by treating each admission as a chronological sequence of daily multimodal events, integrating Electronic Health Record updates and Chest X‑ray findings. It uses disease‑specific supervised contrastive learning to shape a diagnosis‑aware latent space and preserves day‑level clinical signals that other methods often compress. Experiments on MIMIC‑IV and MIMIC‑CXR datasets show state‑of‑the‑art performance and the model can highlight "Critical Days" for actionable real‑time risk stratification.

By Minjun Kim, Jong Hak Moon
arXiv Machine Learning
Jul 7

OC-Distill: Ontology-aware Contrastive Learning with Cross-Modal Distillation for ICU Risk Prediction

arXiv:2604. 16878v2 Announce Type: replace Abstract: Early prediction of severe clinical deterioration and remaining length of stay can enable timely intervention and better resource allocation in high-acuity settings such as the ICU.

By Zhongyuan Liang, Junhyung Jo, Hyang-Jung Lee, Sang Kyu Kim, Irene Y. Chen
arXiv AI
Jun 17

Probing, Fusion, and Trustworthiness: A Systematic Evaluation of Foundation Model Representations for Multimodal Cancer Analysis

arXiv:2606. 17115v1 Announce Type: cross Abstract: Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored.

By Jingyu Hu, Giuseppe Tripodi, Reed Naidoo, Sarah F. McGough, Tapabrata Chakraborti
arXiv AI
Sep 10

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

NOAH is a generative transformer that learns the full multimodal patient journey by integrating bidirectional time and a variational latent space. Trained on over 559 million clinical events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual intervention simulation, yielding strong performance on clinical outcomes, ICD chapters, comorbidities, and time‑to‑event prediction.

By Tobias Susetzky, Raphael Rehms, Dmitrii Seletkov, \"Ozg\"un Turgut, Michelle Espranita Liman, Lisa Steinhelfer, Rickmer Braren, Daniel Rueckert
Hugging Face Trending Papers
Sep 8

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

NOAH is a generative transformer that models the entire multimodal patient journey by integrating bidirectional time and a variational latent space to capture continuous, stochastic clinical trajectories. Trained on over 559 million events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual simulations, yielding strong predictive performance across 15 ICD chapters, 29 comorbidities, and time‑to‑event outcomes.

arXiv Machine Learning
Jul 31

TIER-MoE: Trust-Informed Expert Routing via Conditional Modality Risk for Multimodal Fusion in Biomedical Classification

arXiv:2607. 27289v1 Announce Type: new Abstract: The promise of multimodal fusion lies in combining complementary sources of evidence, yet more evidence does not always yield a better prediction.

By Yu Chang, Anzhe Cheng, Chenwei Wu, Zhuoran Wang, Jiahao Chen, Tamoghna Chattopadhyay, Sophia I. Thomopoulos, Paul M. Thompson, Liyue Shen, Paul Bogdan
arXiv AI
Jun 30

IMCBench: A benchmark for multimodal LLMs in Image-grounded Medical Conversations

arXiv:2606. 28556v1 Announce Type: new Abstract: Recent advances in large language models and vision-language models have enabled reasoning over multimodal data, offering opportunities for clinical applications such as decision support and triaging.

By Maria Xenochristou, Ashutosh Joshi, Korosh Vatanparvar, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Anchal Nema, Nivedita Wadhwa, Prashams S Jain, Rebecca Abraham, Will Kimbrough, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv Machine Learning
Sep 7

SMILE: Self-Explainable Multimodal Information Bottleneck for Medical Diagnosis

The paper introduces SMILE, a self‑explainable multimodal information bottleneck framework for medical diagnosis. It jointly optimizes predictive accuracy and modality‑specific explainability by selecting the most informative elements within each data modality. Experiments on diverse medical datasets show strong diagnostic performance, including a 9.1‑percentage‑point accuracy gain on the iCTCF dataset, and provide transparent, modality‑aware explanations that enhance both explainability and generalization.

By Yuqing Yang, Alexander Schmatz, Zhaozhao Ma, Changkyu Choi, Robert Jenssen, Shujian Yu