arXiv:2607. 21307v1 Announce Type: cross Abstract: The reliance on unstructured free text for documenting clinical trial protocols creates a significant barrier to automated reasoning, cohort discovery, and trial simulation.
Understanding the temporal progression of symptoms in clinical narratives is critical for disease monitoring, safety surveillance, and causality assessment. Clinical narratives, however, rarely provide explicit temporal anchors.
arXiv:2601. 06300v2 Announce Type: replace-cross Abstract: Clinical trial amendments frequently introduce delays, increased costs, and administrative burden, with eligibility criteria being the most commonly amended component.
arXiv:2609.24620v1 Announce Type: new Abstract: Answering epidemiological questions from real-world clinical data requires medical coding, schema-aware SQL, and validation of implicit choices about p...
arXiv:2608. 12779v1 Announce Type: cross Abstract: Understanding the temporal progression of symptoms in clinical narratives is critical for disease monitoring, safety surveillance, and causality assessment.
arXiv:2605. 30295v2 Announce Type: replace-cross Abstract: Large language models (LLMs) show promise for clinical reasoning and decision support, but evaluation in realistic, electronic health record-congruent settings remains limited.
ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.
arXiv:2608.21948v1 Announce Type: new Abstract: Complex clinical reasoning requires models to update diagnostic hypotheses as new evidence emerges and to coordinate different medical specialities und...
HERMES is a graph-based framework that uses only clinical text to predict patient outcomes. It builds personalized Knowledge Graphs from clinical notes via Large‑Language‑Model‑guided extraction and Contrastive Logic Modeling, capturing temporal dynamics and treatment changes. A Graph Attention Network then synthesizes patient representations, and experiments on MIMIC‑III and MIMIC‑IV show HERMES outperforms text‑only baselines for in‑hospital mortality and 30‑day readmission prediction.
arXiv:2608. 05375v1 Announce Type: new Abstract: Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity.
arXiv:2606. 02802v1 Announce Type: new Abstract: Large language models (LLMs) exhibit strong natural-language reasoning abilities for clinical decision support, but struggle to effectively model structured longitudinal electronic health records (EHRs).
arXiv:2608.23248v1 Announce Type: cross Abstract: Traditional clinical prediction models rely on task-specific pipelines and curated, structured data, which scale poorly and underutilize unstructured...
arXiv:2608.21186v1 Announce Type: new Abstract: Surgical procedures such as laparoscopic appendectomy are complex, high-stakes processes, yet formalizing their workflows for decision support remains...