arXiv:2608. 05375v1 Announce Type: new Abstract: Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity.
arXiv:2606. 01094v1 Announce Type: new Abstract: Clinical order generation serves as a critical bridge between clinical decision-making and real-world practice, translating medical decisions into concrete and executable orders.
arXiv:2609.24480v1 Announce Type: cross Abstract: Deploying Large Language Models (LLMs) in healthcare requires robust performance across two complementary dimensions - diagnostic reasoning: the conv...
arXiv:2607. 15314v1 Announce Type: new Abstract: Healthcare spans high-stakes communication, expert reasoning, and workflow execution, yet specialized LLMs that cover these use cases together remain limited.
arXiv:2603. 03292v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields.
arXiv:2601. 22324v3 Announce Type: replace Abstract: Modern clinical practice relies on evidence-based guidelines implemented as compact scoring systems composed of a small number of interpretable decision rules.
arXiv:2609.24620v1 Announce Type: new Abstract: Answering epidemiological questions from real-world clinical data requires medical coding, schema-aware SQL, and validation of implicit choices about p...
arXiv:2609.15161v1 Announce Type: cross Abstract: Large language model (LLM) driven multi-agent systems have shown promise in complex clinical reasoning, yet existing approaches rely on static strate...
arXiv:2603. 17216v2 Announce Type: replace Abstract: With the advent of AI agents, automated scientific discovery is becoming an increasingly plausible goal.
arXiv:2607. 02983v1 Announce Type: new Abstract: Recent reasoning-centric Large Language Models (LLMs) have made significant strides, yet they predominantly operate on a passive-inference pattern that assumes complete information.
The paper introduces BRIE, a scalable framework that automatically creates question–answer pairs from longitudinal electronic health record notes, validated by nineteen clinicians. It offers a continuously maintainable benchmark for evaluating large language models in clinical settings, addressing limitations of manual, costly, and quickly outdated existing benchmarks. Experiments across nine LLMs and five inference strategies reveal that even state‑of‑the‑art systems often miss clinically important information, especially for synthesis‑heavy queries.
arXiv:2607. 00147v1 Announce Type: new Abstract: Rare disease differential diagnosis is a critical yet arduous clinical task, requiring physicians to identify precise phenotypes from complex, unstructured patient symptoms and execute intricate reasoning within a vast search space.
The paper reviews how Large Language Models (LLMs) are being adapted for medical reasoning, moving beyond single-step answers to systems that can systematically, transparently, and verifiably reason. It introduces a taxonomy of enhancement techniques, split into training-time methods such as supervised fine‑tuning and reinforcement learning, and test-time methods like prompt engineering and multi‑agent systems. The review examines their application across text, image, and code modalities in key clinical areas—diagnosis, education, and treatment planning—and tracks the shift in evaluation benchmarks from simple accuracy to more nuanced assessments of reasoning quality and visual interpretability.