Understanding the temporal progression of symptoms in clinical narratives is critical for disease monitoring, safety surveillance, and causality assessment. Clinical narratives, however, rarely provide explicit temporal anchors.
arXiv:2608. 12779v1 Announce Type: cross Abstract: Understanding the temporal progression of symptoms in clinical narratives is critical for disease monitoring, safety surveillance, and causality assessment.
CliniCIRCA is a modular large‑language‑model framework that reconstructs longitudinal mental‑health patient journeys from raw electronic health record narratives. It temporally classifies clinical events in unstructured discharge summaries without explicit timestamps, producing 15,891 tagged events from 52 summaries and correcting 629 errors to create verified gold‑standard timelines. The framework then generates temporally grounded summaries, compressing each source by 1.52×, and scales to produce 1,000 silver‑standard timelines for training, showing that instruction tuning improves event extraction, temporal tagging, and summarization across models.
The paper introduces a paired benchmark to detect hindsight bias in clinical language models by comparing model responses to questions posed at a clinically relevant cutoff versus the full timeline. It uses 171 case reports (40 sepsis, 131 GLP‑1/diabetes) with both human‑annotated and LLM‑generated time‑series data, evaluating accuracy, hindsight trap rate, answer instability rate, and hindsight bias rate. Results show that exposing models to the full timeline consistently increases hindsight bias, while truncating the timeline mitigates bias without sacrificing accuracy.
arXiv:2610.01938v1 Announce Type: cross Abstract: Exam-style accuracy does not establish whether large language models (LLMs) reason well over clinical records. We define clinical reasoning as integr...
arXiv:2607. 21307v1 Announce Type: cross Abstract: The reliance on unstructured free text for documenting clinical trial protocols creates a significant barrier to automated reasoning, cohort discovery, and trial simulation.
arXiv:2605. 01134v3 Announce Type: replace Abstract: The dominant noun-based modeling paradigm has fundamentally constrained AI development, precluding any adequate representation of the future as an open temporal dimension.
arXiv:2606. 05463v1 Announce Type: new Abstract: Patient safety event triage, determining whether a clinical event is reportable under jurisdiction-specific policy, is a high-stakes task typically performed manually by patient safety experts.
HERMES is a graph-based framework that uses only clinical text to predict patient outcomes. It builds personalized Knowledge Graphs from clinical notes via Large‑Language‑Model‑guided extraction and Contrastive Logic Modeling, capturing temporal dynamics and treatment changes. A Graph Attention Network then synthesizes patient representations, and experiments on MIMIC‑III and MIMIC‑IV show HERMES outperforms text‑only baselines for in‑hospital mortality and 30‑day readmission prediction.
arXiv:2606. 05994v1 Announce Type: new Abstract: Medical knowledge graphs (MKGs) infused with clinical knowledge have been increasingly used to model electronic health records (EHRs) to support interpretable predictions in healthcare domain.
arXiv:2608.21186v1 Announce Type: new Abstract: Surgical procedures such as laparoscopic appendectomy are complex, high-stakes processes, yet formalizing their workflows for decision support remains...
arXiv:2606. 09030v1 Announce Type: cross Abstract: Clinical early warning systems built on electronic health records, in which clinical observations are recorded as irregularly sampled medical time series (ISMTS), must deliver both calibrated risk scores for patient triage and interpretable rationales that clinicians can verify.
arXiv:2605. 07267v2 Announce Type: replace Abstract: Personalized healthcare decisions require reasoning about how physiological and behavioral variables influence an individual patient over time.