ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.
arXiv:2603. 25821v3 Announce Type: replace-cross Abstract: We present Doctorina MedBench, an evaluation framework for agent-based medical AI based on the simulation of physician-patient interactions.
arXiv:2610.34878v1 Announce Type: new Abstract: Disease diagnosis is a key application of large language model (LLM) agents in healthcare. However, existing medical agents are primarily trained and e...
The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.
arXiv:2606. 29746v1 Announce Type: new Abstract: Navigating the deluge of heterogeneous medical data, from academic literature (PubMed) to clinical guidelines (Web) and private knowledge bases, remains a critical bottleneck for evidence-based medicine.
MedResearcher‑R1 is a medical deep‑research agent that uses a Knowledge‑Informed Trajectory Synthesis (KISA) framework to build medical knowledge graphs and generate complex multi‑hop question‑answer pairs, especially for rare medical entities. It also incorporates a medical retrieval engine and general‑purpose tools to reliably synthesize medical evidence. The resulting 2,100+ trajectories across 12 specialties enable supervised fine‑tuning and reinforcement learning, producing a 32B model that outperforms larger proprietary systems on MedBrowseComp and shows strong performance on GAIA and xBench benchmarks.
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
MedCaseAgent is an end‑to‑end agentic reasoning system that generates publication‑quality rare disease case reports from unstructured clinical notes. It combines patient‑level data mining with iterative, tool‑integrated reasoning, dynamically querying medical literature and knowledge bases to maintain clinical fidelity and assess case novelty. The framework is modular, supports multiple backbone LLMs, and is accompanied by a new multimodal case‑report corpus (MedCase‑150K) and evaluation suite (MedCase‑Bench).
Navigating the deluge of heterogeneous medical data, from academic literature (PubMed) to clinical guidelines (Web) and private knowledge bases, remains a critical bottleneck for evidence-based medicine. While commercial black-box tools lack transparency, standard open-source RAG implementations frequently suffer from reasoning drift when handling complex, long-tail queries.
Disease diagnosis is a key application of large language model (LLM) agents in healthcare. However, existing medical agents are primarily trained and evaluated with static question-answering data, pro...
arXiv:2512. 11682v2 Announce Type: replace Abstract: Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents.
arXiv:2603. 03292v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields.
arXiv:2509. 23426v3 Announce Type: replace Abstract: AI scientists are emerging computational systems that serve as collaborative partners in discovery.