arXiv:2608.24723v1 Announce Type: new Abstract: Retinal fundus photography is widely used for screening and monitoring ocular diseases, but many modern classification pipelines rely on deep latent re...
Retinal fundus photography is widely used for screening and monitoring ocular diseases, but many modern classification pipelines rely on deep latent representations and provide limited interpretabilit...
The paper introduces a biology-informed heterogeneous graph representation that models retinal vessel segments, intercapillary areas, and the foveal avascular zone to predict diabetic retinopathy stages from OCTA images. This graph-based approach reframes staging as a graph-level classification task solved with a graph neural network, achieving AUC-ROC values up to 84% and outperforming biomarker-based classifiers, CNNs, and vision transformers. The method also provides detailed, interpretable explanations by precisely localizing abnormal vessels and non-perfusion areas.
arXiv:2606. 16234v1 Announce Type: cross Abstract: Fundus fluorescein angiography (FFA) is critical for assessing retinal vascular abnormalities, but its acquisition is invasive and not always feasible.
Automated diabetic retinopathy (DR) grading from colour fundus photographs can achieve strong predictive performance, but clinical interpretation requires more than an image-level label. It requires understanding how lesion evidence is distributed around retinal vessels and how this evidence relates to quantitative vascular biomarkers.
arXiv:2609.12574v1 Announce Type: new Abstract: Ultra-widefield (UWF) swept-source optical coherence tomography angiography (SS-OCTA) enables large-area retinal vascular imaging, yet vessel segmentat...
The study introduces an explainable OCTA pipeline for Alzheimer’s disease phenotyping that combines vessel segmentation, layer‑specific biomarker extraction, and label‑free phenotyping with large language model (LLM) reporting. Using 117 images from 39 subjects, the segmentation models achieved high ROC‑AUC (0.916–0.970) and Dice scores (0.695–0.781), and six vascular biomarkers were used to create subject‑level profiles for exploratory clustering. LLMs (GPT, Gemini, Llama) produced measurement‑grounded reports evaluated for citation faithfulness and diagnostic caution, offering a transparent, non‑diagnostic link between retinal vascular data and Alzheimer’s research.
arXiv:2406. 13128v2 Announce Type: replace-cross Abstract: Due to the intricate structure of vascular trees, minor segmentation errors can significantly alter connectivity patterns and increase variability in extracted morphological properties.
FPG-Seg is an annotation‑free pipeline for retinal vessel segmentation that combines classical vesselness filtering, Bayesian deep learning, and topology‑aware graph reconstruction. It achieves a clDice score of 0.74–0.78, which is 86–98% of the performance of a fully‑supervised baseline, across four benchmark datasets. The work also presents the first performance benchmark of an annotation‑free vessel segmentation method on the FIVES dataset.
arXiv:2608.29196v1 Announce Type: new Abstract: Optic disc (OD) segmentation is essential for diagnosing ophthalmic pathologies from retinal fundus images. However, prevailing deep learning approache...
arXiv:2607. 04673v1 Announce Type: cross Abstract: Glaucoma is a leading cause of irreversible blindness worldwide, yet most automated diagnosis systems rely on opaque deep-learning models that offer little clinical interpretability.
This study presents four deep‑learning pipelines—two‑dimensional and three‑dimensional—for segmenting age‑related macular degeneration (AMD) and diabetic macular edema (DME) lesions in optical coherence tomography (OCT) images. The models achieve Dice scores between 0.76 and 0.82 and demonstrate strong volumetric and surface calibration (r_vol, r_surf ≥ 0.97) on an in‑domain validation set. Generalization was assessed on the OLIVES clinical cohort using proxy metrics such as biomarker AUROC, central subfield thickness correlation, and longitudinal concordance, showing that the predictions still track clinical biomarkers outside the training distribution, albeit with reduced strength.