arXiv Computer Vision

An Ultra-Widefield Swept-Source OCTA Dataset and a Polar-Gated Mamba Network for Retinal Vessel Segmentation

arXiv Computer Vision
Sep 1

retinalysis-vascx: An explainable software toolbox for the extraction of retinal vascular biomarkers

arXiv:2602.08580v4 Announce Type: replace-cross Abstract: Automatic extraction of retinal vascular biomarkers from color fundus images (CFI) is crucial for large-scale studies of the retinal vasculat...

By Jose D. Vargas Quiros, Michael J. Beyeler, Sofia Ortin Vela, EyeNED Reading Center, Sven Bergmann, Caroline C. W. Klaver, Bart Liefers, VascX Research Consortium
arXiv Computer Vision
Aug 28

Automated 2D and 3D Segmentation of AMD and DME Lesions in OCT

This study presents four deep‑learning pipelines—two‑dimensional and three‑dimensional—for segmenting age‑related macular degeneration (AMD) and diabetic macular edema (DME) lesions in optical coherence tomography (OCT) images. The models achieve Dice scores between 0.76 and 0.82 and demonstrate strong volumetric and surface calibration (r_vol, r_surf ≥ 0.97) on an in‑domain validation set. Generalization was assessed on the OLIVES clinical cohort using proxy metrics such as biomarker AUROC, central subfield thickness correlation, and longitudinal concordance, showing that the predictions still track clinical biomarkers outside the training distribution, albeit with reduced strength.

By Lucia Sundberg, Zhihao Zhao, M. Ali Nasseri
arXiv Computer Vision
Sep 4

Explainable Convolutional Neural Networks for Retinal Fundus Classification and Cutting-Edge Segmentation Models for Retinal Blood Vessels from Fundus Images

The paper presents a two‑pipeline framework for retinal fundus analysis that combines four‑class disease classification with vessel segmentation. It fine‑tunes eight ImageNet‑pretrained CNNs on the FIVES dataset, applies five gradient‑based explanation methods to assess model interpretability, and benchmarks ten U‑Net variants—including transformer‑based and attention‑enhanced architectures—on the FIVES and DRIVE datasets. The best classification results come from ResNet101 (94.17% accuracy), while the strongest segmentation performance is achieved by Attention U‑Net with a ResNet101V2 backbone, improving DRIVE IoU from 60.80% to 64.83%.

By Fatema Tuj Johora Faria, Mukaffi Bin Moin, Pronay Debnath, Asif Iftekher Fahim, Faisal Muhammad Shah
arXiv Computation and Language
Sep 7

Retinal OCTA Phenotyping with LLM Reporting for Alzheimer's Disease

The study introduces an explainable OCTA pipeline for Alzheimer’s disease phenotyping that combines vessel segmentation, layer‑specific biomarker extraction, and label‑free phenotyping with large language model (LLM) reporting. Using 117 images from 39 subjects, the segmentation models achieved high ROC‑AUC (0.916–0.970) and Dice scores (0.695–0.781), and six vascular biomarkers were used to create subject‑level profiles for exploratory clustering. LLMs (GPT, Gemini, Llama) produced measurement‑grounded reports evaluated for citation faithfulness and diagnostic caution, offering a transparent, non‑diagnostic link between retinal vascular data and Alzheimer’s research.

By Progga Paromita Dutta, Jeba Maliha, Md Rafiul Kabir