arXiv Machine Learning

GlaKG: A Biomarker-Centric Fundus Knowledge Graph for Explainable Glaucoma Diagnosis and Risk Assessment

arXiv:2607. 04673v1 Announce Type: cross Abstract: Glaucoma is a leading cause of irreversible blindness worldwide, yet most automated diagnosis systems rely on opaque deep-learning models that offer little clinical interpretability.

arXiv Machine Learning
Sep 17

Interpretable Retinal Disease Prediction Using Biology-Informed Heterogeneous Graph Representations

The paper introduces a biology-informed heterogeneous graph representation that models retinal vessel segments, intercapillary areas, and the foveal avascular zone to predict diabetic retinopathy stages from OCTA images. This graph-based approach reframes staging as a graph-level classification task solved with a graph neural network, achieving AUC-ROC values up to 84% and outperforming biomarker-based classifiers, CNNs, and vision transformers. The method also provides detailed, interpretable explanations by precisely localizing abnormal vessels and non-perfusion areas.

By Laurin Lux, Alexander H. Berger, Maria Romeo Tricas, Richard Rosen, Alaa E. Fayed, Sobha Sivaprasada, Linus Kreitner, Jonas Weidner, Martin J. Menten, Daniel Rueckert, Johannes C. Paetzold
arXiv AI
Aug 21

MKG-CARE: Case-Aware Reasoning with Multimodal Knowledge Graphs for Explainable Medical Image Diagnosis

arXiv:2605. 22547v3 Announce Type: replace-cross Abstract: Medical image diagnosis has achieved significant progress with deep learning, yet existing methods often rely on isolated visual evidence and lack the ability to effectively leverage similar cases and external knowledge.

By Yiming Xu, Yixuan Liu, Yuhang Zhang, Ling Zheng, Yihan Wang, Qi Song
arXiv AI
Sep 10

DL$^3$M: A Vision-to-Language Framework for Expert-Level Medical Reasoning through Deep Learning and Large Language Models

arXiv:2512.13742v3 Announce Type: replace-cross Abstract: Medical image classifiers detect gastrointestinal diseases well, but they do not explain their decisions. Large language models can generate...

By Md. Najib Hasan (Wichita State University, USA), Imran Ahmad (Wichita State University, USA), Sourav Basak Shuvo (Khulna University of Engineering and Technology, Bangladesh), Md. Mahadi Hasan Ankon (Khulna University of Engineering and Technology, Bangladesh), Nazmul Siddique (Ulster University, UK), Hui Wang (Queen's University Belfast, UK)
arXiv Machine Learning
Aug 11

Disentangling Co-Occurring Retinal Pathologies with Saliency-Guided Sparse Expert Routing

arXiv:2608. 09752v1 Announce Type: cross Abstract: Retinal fundus images frequently exhibit multiple co-occurring pathologies, yet standard deep learning classifiers apply static, identical computation to every image regardless of the underlying disease distribution.

By Nagur Shareef Shaik, Jeongwoo Park, Yeong-Jin Kim, Jaeuk Jung, Hyunjung Oh, Dong Hye Ye
arXiv Machine Learning
Jul 24

Counterfactual Explainability Framework With CycleGAN And Counterfactual-Classifier Alignnment Score for Retinal Disease Classification

arXiv:2607. 21068v1 Announce Type: new Abstract: Automated detection of vision impairing retina-based ocular conditions from fundus images is important for early screening, timely referral and reducing dependency on specialist-only assessment, for which neural network-based deep learning (DL) models have been widely utilized.

By Kritanu Chattopadhyay, Sayanjit Singha Roy, Soumya Chatterjee
arXiv AI
Jun 11

OpenMedReason: Scientific Reasoning Supervision for Medical Vision-Language Models

arXiv:2606. 12169v1 Announce Type: cross Abstract: High-stakes clinical use of large vision-language models (LVLMs) requires reasoning that is grounded in visual evidence and clinical knowledge, not just correct final answers.

By Negin Baghbanzadeh, Pritam Sarkar, Michael Colacci, Abeer Badawi, Adibvafa Fallahpour, Arash Afkanpour, Leonid Sigal, Ali Etemad, Elham Dolatabadi
arXiv AI
Aug 20

OptiModNet: A UNet-Transformer Hybrid with Grouped-Query and Channel Attention for Optic Disc and Cup Segmentation

OptiModNet is a lightweight UNet‑Transformer hybrid designed for optic disc and cup segmentation. It incorporates grouped‑query and channel attention across multiple stages, along with an Aggregated Pyramid Loss to improve gradient flow and structural consistency. Evaluated on the REFUGE2 dataset, it surpasses existing methods by over 2.5 % while using only 3.73 GFLOPs and 1.93 M parameters.

By Soumili Ghosh, Debapriya Roy, Aryan Das, Bikash Santra