The paper introduces a biology-informed heterogeneous graph representation that models retinal vessel segments, intercapillary areas, and the foveal avascular zone to predict diabetic retinopathy stages from OCTA images. This graph-based approach reframes staging as a graph-level classification task solved with a graph neural network, achieving AUC-ROC values up to 84% and outperforming biomarker-based classifiers, CNNs, and vision transformers. The method also provides detailed, interpretable explanations by precisely localizing abnormal vessels and non-perfusion areas.
By Laurin Lux, Alexander H. Berger, Maria Romeo Tricas, Richard Rosen, Alaa E. Fayed, Sobha Sivaprasada, Linus Kreitner, Jonas Weidner, Martin J. Menten, Daniel Rueckert, Johannes C. Paetzold
arXiv:2606. 14828v1 Announce Type: cross Abstract: Leptomeningeal collaterals (LMCs) are an important prognostic factor in acute ischemic stroke.
By Junyong Cao, Hakim Baazaoui, Chinmay Prabhakar, Suprosanna Shit, Lukas Bastian Otto, Susanne Wegener, Bjoern Menze, Ezequiel de la Rosa
arXiv:2602.08580v4 Announce Type: replace-cross
Abstract: Automatic extraction of retinal vascular biomarkers from color fundus images (CFI) is crucial for large-scale studies of the retinal vasculat...
By Jose D. Vargas Quiros, Michael J. Beyeler, Sofia Ortin Vela, EyeNED Reading Center, Sven Bergmann, Caroline C. W. Klaver, Bart Liefers, VascX Research Consortium
arXiv:2608.24723v1 Announce Type: new
Abstract: Retinal fundus photography is widely used for screening and monitoring ocular diseases, but many modern classification pipelines rely on deep latent re...
By Xiaoyan Li, Shixin Xu, Arvind Gupta, Huaxiong Huang
Retinal fundus photography is widely used for screening and monitoring ocular diseases, but many modern classification pipelines rely on deep latent representations and provide limited interpretabilit...
ReG-SAM is a SAM-based framework designed for 2D vessel segmentation in medical images. It introduces reference graph prompt embeddings (GPEs) and vascular prototype embeddings (VPEs) to capture global spatial and fine-grained modality-specific vessel features, respectively. By building a modality-wise vascular database and learning these embeddings from reference masks, ReG-SAM consistently outperforms existing baselines across 19 datasets, especially on thin vessels.
By Donghang Lyu, Zichen Zhang, Oleh Dzyubachyk, Marius Staring