arXiv Machine Learning

Interpretable Retinal Disease Prediction Using Biology-Informed Heterogeneous Graph Representations

The paper introduces a biology-informed heterogeneous graph representation that models retinal vessel segments, intercapillary areas, and the foveal avascular zone to predict diabetic retinopathy stages from OCTA images. This graph-based approach reframes staging as a graph-level classification task solved with a graph neural network, achieving AUC-ROC values up to 84% and outperforming biomarker-based classifiers, CNNs, and vision transformers. The method also provides detailed, interpretable explanations by precisely localizing abnormal vessels and non-perfusion areas.

arXiv Machine Learning
Jul 7

GlaKG: A Biomarker-Centric Fundus Knowledge Graph for Explainable Glaucoma Diagnosis and Risk Assessment

arXiv:2607. 04673v1 Announce Type: cross Abstract: Glaucoma is a leading cause of irreversible blindness worldwide, yet most automated diagnosis systems rely on opaque deep-learning models that offer little clinical interpretability.

By Cheng Huang, Jia Zhang, Yi Jiang, Yang Liu, Karanjit Kooner, Yadi Liu, Tsengdar Lee, Yang Xie, Wenqi Shi, Guanghua Xiao
arXiv Computer Vision
Sep 1

retinalysis-vascx: An explainable software toolbox for the extraction of retinal vascular biomarkers

arXiv:2602.08580v4 Announce Type: replace-cross Abstract: Automatic extraction of retinal vascular biomarkers from color fundus images (CFI) is crucial for large-scale studies of the retinal vasculat...

By Jose D. Vargas Quiros, Michael J. Beyeler, Sofia Ortin Vela, EyeNED Reading Center, Sven Bergmann, Caroline C. W. Klaver, Bart Liefers, VascX Research Consortium
arXiv Machine Learning
Jul 24

Counterfactual Explainability Framework With CycleGAN And Counterfactual-Classifier Alignnment Score for Retinal Disease Classification

arXiv:2607. 21068v1 Announce Type: new Abstract: Automated detection of vision impairing retina-based ocular conditions from fundus images is important for early screening, timely referral and reducing dependency on specialist-only assessment, for which neural network-based deep learning (DL) models have been widely utilized.

By Kritanu Chattopadhyay, Sayanjit Singha Roy, Soumya Chatterjee
arXiv AI
3d ago

ReG-SAM: Reference Graph-Driven SAM for 2D Foundational Vessel Segmentation

ReG-SAM is a SAM-based framework designed for 2D vessel segmentation in medical images. It introduces reference graph prompt embeddings (GPEs) and vascular prototype embeddings (VPEs) to capture global spatial and fine-grained modality-specific vessel features, respectively. By building a modality-wise vascular database and learning these embeddings from reference masks, ReG-SAM consistently outperforms existing baselines across 19 datasets, especially on thin vessels.

By Donghang Lyu, Zichen Zhang, Oleh Dzyubachyk, Marius Staring
arXiv Computer Vision
6d ago

Context-aware Skin Cancer Epithelial Cell Classification with Scalable Graph Transformers

The paper introduces scalable Graph Transformers for classifying healthy versus tumor epithelial cells in whole-slide images of cutaneous squamous cell carcinoma. By constructing a full‑WSI cell graph and incorporating morphological, texture, and neighboring cell class features, the proposed SGFormer and DIFFormer models outperform traditional image‑based methods, achieving balanced accuracies above 85% on single‑WSI tests and 83.6% on multi‑WSI evaluations. The study demonstrates that preserving tissue‑level context through graph representations improves classification of morphologically similar cell types.

By Lucas Sanc\'er\'e, No\'emie Moreau, Katarzyna Bozek
arXiv Machine Learning
Aug 11

Disentangling Co-Occurring Retinal Pathologies with Saliency-Guided Sparse Expert Routing

arXiv:2608. 09752v1 Announce Type: cross Abstract: Retinal fundus images frequently exhibit multiple co-occurring pathologies, yet standard deep learning classifiers apply static, identical computation to every image regardless of the underlying disease distribution.

By Nagur Shareef Shaik, Jeongwoo Park, Yeong-Jin Kim, Jaeuk Jung, Hyunjung Oh, Dong Hye Ye