Domain Elastic Transform (DET) is a grid‑free, probabilistic framework that jointly aligns geometry and high‑dimensional vector‑valued functions on irregular sparse manifolds, such as those found in spatial transcriptomics. By treating data as functions rather than voxelized images, DET performs unsupervised, scalable registration through sampled point alignment and displacement interpolation, guided by a joint spatial‑functional Bayesian likelihood. Evaluations on MERFISH mouse‑brain slices and Stereo‑seq mouse‑embryo atlases show DET achieving superior spatial overlap and topology compared to existing pipelines, with an accelerated variant delivering high label‑transfer accuracy.
The growing number of medical vision foundation models highlights the need for effective model selection. However, mainstream selection methods rely on exhaustive fine-tuning, which is computationally expensive.
arXiv:2608.24025v1 Announce Type: new Abstract: Endpoint-only unsupervised 4D medical image interpolation synthesizes intermediate volumes from sparsely sampled sequences with only the start and end...
arXiv:2607. 23343v1 Announce Type: cross Abstract: Intraoperative 2D/3D registration aligns preoperative CT volumes with intraoperative X-ray or fluoroscopic images and is essential for image-guided interventions.
arXiv:2608. 08173v1 Announce Type: cross Abstract: Longitudinal MRI enables sensitive measurement of structural brain change for studying aging and neurodegenerative disease.
arXiv:2507. 04704v3 Announce Type: replace-cross Abstract: Understanding how cellular morphology, gene expression, and spatial context jointly shape tissue function is a central challenge in biology.
The paper introduces a geometry‑guided sampling operator that directs feature sampling rather than altering convolution kernels in 3D encoder‑decoder networks. By predicting local orientations and bounded step sizes, the operator samples symmetrically around each voxel, generating compact geometric and boundary cues that improve fine‑structure segmentation. Replacing stride‑1 and stride‑2 operations in a 3D U‑Net yields consistent gains on BraTS, MSD Hepatic Vessel, and TDSC‑ABUS datasets, with better boundary metrics and fewer parameters, and the operator can be integrated into other backbones without architectural changes.
arXiv:2605.16742v3 Announce Type: replace Abstract: Cortical surface registration is often driven by local geometric descriptors (e.g., sulcal depth and curvature). While this approach achieves geome...
arXiv:2606. 03644v1 Announce Type: new Abstract: Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times.
arXiv:2511. 03826v4 Announce Type: replace-cross Abstract: Accurate and efficient registration of whole slide images (WSIs) is essential for high-resolution, nuclei-level analysis in multi-stained tissue slides.
The paper introduces a deep learning pipeline that rapidly and accurately registers 3D high‑resolution Drosophila larval brain volumes to a shared anatomical reference. Unlike traditional methods that require per‑case optimization and minutes per brain, the trained network performs a single forward pass, handling volumes with many more voxels and maintaining high accuracy even as image quality declines. The authors benchmarked their approach against eleven classical and seven learned baselines, achieving a 23‑percentage‑point improvement in landmark‑based mutual information and registering brains one to two orders of magnitude faster.
BridgeMatch is a two‑stage generative solver that preserves the full soft matching matrix for 3D deformable registration. Stage I uses denoising diffusion to estimate a global matching matrix at a coarse resolution, then lifts it to high resolution while maintaining hierarchy and rank constraints. Stage II refines this lifted matrix via a conditional transport bridge, implemented with either a deterministic Flow Matching ODE or a stochastic Brownian‑bridge SDE, and demonstrates improved correspondence accuracy and registration performance on 4DMatch, 4DLoMatch, CAPE, and DeepDeform datasets, especially in low‑overlap scenarios.
arXiv:2608. 14924v1 Announce Type: cross Abstract: Spatial transcriptomics (ST) links tissue morphology with molecular programs, motivating multimodal pretraining methods that align histology images with gene expression.