Domain Elastic Transform (DET) is a grid‑free, probabilistic framework that jointly aligns geometry and high‑dimensional vector‑valued functions on irregular sparse manifolds, such as those found in spatial transcriptomics. By treating data as functions rather than voxelized images, DET performs unsupervised, scalable registration through sampled point alignment and displacement interpolation, guided by a joint spatial‑functional Bayesian likelihood. Evaluations on MERFISH mouse‑brain slices and Stereo‑seq mouse‑embryo atlases show DET achieving superior spatial overlap and topology compared to existing pipelines, with an accelerated variant delivering high label‑transfer accuracy.
By Osamu Hirose, Emanuele Rodola
The growing number of medical vision foundation models highlights the need for effective model selection. However, mainstream selection methods rely on exhaustive fine-tuning, which is computationally expensive.
arXiv:2609.15669v1 Announce Type: cross
Abstract: Multimodal image registration is a key component of many clinical workflows, yet it remains challenging because corresponding anatomical structures o...
By Matteo Barbieri, Giammarco La Barbera, Juan Pablo De La Plata, Sabine Sarnacki, Isabelle Bloch, Pietro Gori
The paper introduces a geometry‑guided sampling operator that directs feature sampling rather than altering convolution kernels in 3D encoder‑decoder networks. By predicting local orientations and bounded step sizes, the operator samples symmetrically around each voxel, generating compact geometric and boundary cues that improve fine‑structure segmentation. Replacing stride‑1 and stride‑2 operations in a 3D U‑Net yields consistent gains on BraTS, MSD Hepatic Vessel, and TDSC‑ABUS datasets, with better boundary metrics and fewer parameters, and the operator can be integrated into other backbones without architectural changes.
By Sizhe Wang, Himashi Peiris, Zhaolin Chen
The paper introduces a Geometric-to-Semantic Spherical Transfer Learning framework for labeling cortical sulci on brain surfaces. It first pre‑trains a spherical encoder on ~30,000 unlabeled UK Biobank subjects using only curvature and depth, then injects sulcal fundi lines as a soft‑initialized Topological Prior Injector to bridge the geometric‑semantic gap. Experiments show the method surpasses fully supervised baselines, achieving a mean Dice score of 0.77 and delivering the largest gains on variable and tertiary sulci.
By Saeb Tounsi, Jo\"el Chavas, Pietro Gori, Vincent Frouin, Denis Rivi\`ere, Jean-Fran\c{c}ois Mangin
arXiv:2510. 24342v2 Announce Type: replace Abstract: Prior brain-AI alignment studies are typically constrained by specific inputs and tasks, limiting their ability to capture organizational properties across models with different modalities.
By Silin Chen, Yuzhong Chen, Caiwei Wang, Zifan Wang, Junhao Wang, Zifeng Jia, Keith M Kendrick, Tuo Zhang, Lin Zhao, Dezhong Yao, Tianming Liu, Xi Jiang
The paper introduces MedPCFM‑TED, a one‑step distillation framework that uses teacher‑guided endpoint supervision and geometric matching losses to generate cranial implants from point clouds. It outperforms existing one‑step methods on the SkullBreak benchmark, remains competitive on SkullFix, and achieves a generation time of about 0.04 s per sample. The approach demonstrates that rapid, high‑quality implant generation is possible without multiple neural evaluations during inference.
By Kamil Kwarciak, Marek Wodzinski
arXiv:2608. 15266v1 Announce Type: cross Abstract: Functional connectome analysis examines brain-region interactions to understand and identify disorders such as autism spectrum disorder and Alzheimer's disease.
By Sijing Wu, Dongyuan Li, Miaoting Huang, Weiwei Ye, Ying Zhang, Feng Xia, Renhe Jiang
arXiv:2606. 13188v1 Announce Type: cross Abstract: Building patient-specific cardiac models sits at the heart of precision cardiology, yet getting those models into clinical use keeps running into the same wall: mesh generation is slow, messy, and frustrating.
By Abhishek H S, Akash Ganamukhi, Abhimanyu Suresh, Aditya G Hiremath, Prasad B Honnavalli, Adithya Balasubramanyam
arXiv:2605. 24395v2 Announce Type: replace Abstract: Alignment plays a fundamental role in many machine learning problems, such as multi-network analysis, multimodal learning, and point cloud registration.
By Qi Yu, Ruizhong Qiu, Zhichen Zeng, My T. Thai, Huan Liu, Hanghang Tong
arXiv:2606. 26898v1 Announce Type: cross Abstract: Diffusion MRI (dMRI) tractography enables non-invasive reconstruction of white-matter pathways, but its accuracy is fundamentally limited by indirect, low-resolution measurements of axonal organization.
By Kyriaki-Margarita Bintsi, Sparsh Makharia, Ya\"el Balbastre, Joselyn Romero Avila, Julia F. Lehman, Suzanne N. Haber, Anastasia Yendiki
The paper introduces a transfer‑learning framework that pre‑trains an implicit neural representation (INR) on a high‑resolution diffusion MRI template and then adapts it to individual subjects through registration and fine‑tuning. This approach enables native single‑subject super‑resolution, achieving a 4× through‑plane up‑sampling from 5 mm to 1.25 mm on Human Connectome Project data. Compared to a recent baseline, the method reduces NRMSE by 36–49 % and increases FSIM by 24–43 %, while training 6× faster and outperforming other INR‑based techniques on both image quality and domain‑specific metrics.
By Abdulkader Ghandoura, Marsil Zakour, William Consagra, Yogesh Rathi