The paper investigates whether uncertainty can act as a proxy for semantic correctness in diffusion-based medical image synthesis, specifically for generating contrast‑enhanced CT (CECT) from non‑contrast CT (NCCT). Using the AortaDiff framework, which produces both CECT images and lumen segmentations, the authors compare six uncertainty estimation methods across pixel, region, and image levels, including their ability to detect out‑of‑distribution cases. They find that uncertainty is informative at all spatial scales, remains useful under distribution shift, and that MCDropout, in particular, offers reliable quality filtering with no extra training cost.
arXiv:2609.17169v1 Announce Type: cross Abstract: Forecasting anatomical changes such as tumor growth and neurodegeneration is a challenging generative vision task. Morphological evolution is subtle...
arXiv:2603. 04024v2 Announce Type: replace-cross Abstract: Ambiguous 3D medical image segmentation often involves boundaries where different expert delineations are non-identical yet clinically plausible.
arXiv:2604. 15271v3 Announce Type: replace-cross Abstract: Reliable uncertainty estimation is critical for medical image segmentation, where automated contours feed downstream quantification and clinical decision support.
arXiv:2607. 22727v1 Announce Type: cross Abstract: Medical image segmentation models often report high benchmark accuracy under ideal imaging conditions, yet their failures under clinical degradation can be quiet: sensor noise, patient motion, low- resolution acquisition, and contrast variability may all alter model behavior without producing an obvious warning.
arXiv:2608. 14766v1 Announce Type: cross Abstract: Uncertainty estimation is critical for the safe clinical deployment of deep learning in medical image segmentation, with aleatoric uncertainty theoretically designed to capture irreducible data ambiguity.
arXiv:2602.14512v3 Announce Type: replace Abstract: Autoregressive pretraining has been key to the scalability of large language models, yet medical generative foundation models remain predominantly...
arXiv:2607. 29337v1 Announce Type: cross Abstract: Background and Objective: Generating realistic medical images with anatomically accurate segmentation masks helps address the shortage of annotated data in medical imaging, particularly in optical coherence tomography (OCT) of mouse eyes, where manual retinal layer delineation is labour-intensive due to tiny structures and required expertise, resulting in scarce datasets.
arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
The paper introduces an uncertainty‑driven training framework for 3D CT lung nodule classification that uses validation‑based uncertainty estimates to reweight the loss, aiming to improve predictive performance and probability calibration. Two uncertainty quantification methods—Monte Carlo Dropout and Evidential Deep Learning—are evaluated across multiple backbone architectures (ResNet, DenseNet, EfficientNet, ViT, Swin) on the LIDC‑IDRI and NoduleMNIST3D datasets. The approach yields comparable classification accuracy to conventional training while substantially reducing expected calibration error, especially on convolutional backbones, and shows that simple temperature scaling can also achieve strong calibration.
arXiv:2509. 21913v2 Announce Type: replace-cross Abstract: Background: Cone-beam computed tomography CBCT is a commonly used modality for image guided radiotherapy.
The paper introduces MedSegLatDiff, a diffusion-based framework that combines a variational autoencoder (VAE) with a latent diffusion model for medical image segmentation. By compressing images into a low-dimensional latent space, the method reduces noise and speeds up training, while a weighted cross‑entropy loss preserves tiny structures such as small nodules. Evaluated on ISIC‑2018, CVC‑Clinic, and LIDC‑IDRI datasets, MedSegLatDiff achieves state‑of‑the‑art Dice and IoU scores, generates diverse segmentation hypotheses, and produces confidence maps that enhance interpretability and reliability for clinical deployment.
The paper introduces an unsupervised approach to medical image segmentation by training a Denoising Diffusion Probabilistic Model (DDPM) on 21 unlabeled abdominal CT scans to learn anatomical features. The encoder weights from the DDPM are transferred to a U‑Net for downstream segmentation on the BTCV multi‑organ dataset, resulting in a significant Dice score improvement for liver segmentation from 0.75 to 0.93. In low‑data regimes, diffusion‑pretrained models retain robust performance, achieving high Dice scores even with only 10% of labeled data.