The paper introduces an uncertainty‑driven training framework for 3D CT lung nodule classification that uses validation‑based uncertainty estimates to reweight the loss, aiming to improve predictive performance and probability calibration. Two uncertainty quantification methods—Monte Carlo Dropout and Evidential Deep Learning—are evaluated across multiple backbone architectures (ResNet, DenseNet, EfficientNet, ViT, Swin) on the LIDC‑IDRI and NoduleMNIST3D datasets. The approach yields comparable classification accuracy to conventional training while substantially reducing expected calibration error, especially on convolutional backbones, and shows that simple temperature scaling can also achieve strong calibration.
By Giuseppe Tripodi, Alessandro De Rosis, Saleh Rezaeiravesh
arXiv:2603.18792v3 Announce Type: replace
Abstract: Uncertainty quantification (UQ) is crucial in safety-critical applications such as medical image segmentation. Total uncertainty is typically decom...
By Jakob L{\o}nborg Christensen, Vedrana Andersen Dahl, Morten Rieger Hannemose, Anders Bjorholm Dahl, Christian F. Baumgartner
arXiv:2607. 22727v1 Announce Type: cross Abstract: Medical image segmentation models often report high benchmark accuracy under ideal imaging conditions, yet their failures under clinical degradation can be quiet: sensor noise, patient motion, low- resolution acquisition, and contrast variability may all alter model behavior without producing an obvious warning.
By Pranav Kaliaperumal, Manisha Kaliaperumal
arXiv:2609.39429v1 Announce Type: cross
Abstract: Uncertainty Quantification (UQ) is a key requirement for trustworthy AI in high-stakes medical image analysis. In this work, we evaluate UQ in a mult...
By Gonzalo Esteban Mosquera Rojas, Sebastian R. van der Voort, Carolin M. Pirkl, Sandeep Kaushik, Marion Smits, Stefan Klein
arXiv:2603. 04024v2 Announce Type: replace-cross Abstract: Ambiguous 3D medical image segmentation often involves boundaries where different expert delineations are non-identical yet clinically plausible.
By Chao Wu, Mahesh Bhosale, Kangxian Xie, Pouya Karimian, David Doermann, Mingchen Gao
arXiv:2606. 15837v1 Announce Type: cross Abstract: Deep neural networks (DNNs) frequently fail to generalize to out-of-distribution (OOD) medical images because of variations in scanners and acquisition protocols.
By Jimut B. Pal, Suyash P. Awate