The paper introduces an uncertainty‑driven training framework for 3D CT lung nodule classification that uses validation‑based uncertainty estimates to reweight the loss, aiming to improve predictive performance and probability calibration. Two uncertainty quantification methods—Monte Carlo Dropout and Evidential Deep Learning—are evaluated across multiple backbone architectures (ResNet, DenseNet, EfficientNet, ViT, Swin) on the LIDC‑IDRI and NoduleMNIST3D datasets. The approach yields comparable classification accuracy to conventional training while substantially reducing expected calibration error, especially on convolutional backbones, and shows that simple temperature scaling can also achieve strong calibration.
By Giuseppe Tripodi, Alessandro De Rosis, Saleh Rezaeiravesh
arXiv:2603.18792v3 Announce Type: replace
Abstract: Uncertainty quantification (UQ) is crucial in safety-critical applications such as medical image segmentation. Total uncertainty is typically decom...
By Jakob L{\o}nborg Christensen, Vedrana Andersen Dahl, Morten Rieger Hannemose, Anders Bjorholm Dahl, Christian F. Baumgartner
arXiv:2607. 22727v1 Announce Type: cross Abstract: Medical image segmentation models often report high benchmark accuracy under ideal imaging conditions, yet their failures under clinical degradation can be quiet: sensor noise, patient motion, low- resolution acquisition, and contrast variability may all alter model behavior without producing an obvious warning.
By Pranav Kaliaperumal, Manisha Kaliaperumal
arXiv:2609.39429v1 Announce Type: cross
Abstract: Uncertainty Quantification (UQ) is a key requirement for trustworthy AI in high-stakes medical image analysis. In this work, we evaluate UQ in a mult...
By Gonzalo Esteban Mosquera Rojas, Sebastian R. van der Voort, Carolin M. Pirkl, Sandeep Kaushik, Marion Smits, Stefan Klein
arXiv:2603. 04024v2 Announce Type: replace-cross Abstract: Ambiguous 3D medical image segmentation often involves boundaries where different expert delineations are non-identical yet clinically plausible.
By Chao Wu, Mahesh Bhosale, Kangxian Xie, Pouya Karimian, David Doermann, Mingchen Gao
arXiv:2606. 15837v1 Announce Type: cross Abstract: Deep neural networks (DNNs) frequently fail to generalize to out-of-distribution (OOD) medical images because of variations in scanners and acquisition protocols.
By Jimut B. Pal, Suyash P. Awate
The study explores how adding anatomical priors and active learning can improve the accuracy of deep learning models for segmenting the Clinical Target Volume (CTV) in gastric cancer radiotherapy. Using 100 retrospective CT scans, an nnU‑Net model trained on 10 expert‑contoured cases was enhanced with voxel‑wise anatomical prior maps and iterative active learning over four rounds. The combined approach raised the mean Dice Similarity Coefficient from 0.84 to 0.87, demonstrating that both techniques individually and together improve segmentation performance and generalizability.
By Phillip Chlap, Mark Lee, Trevor Leong, Matthew Field, Jason Dowling, Hang Min, Julie Chu, Jennifer Tan, Phillip K. Tran, Tomas Kron, Annette Haworth, Martin A. Ebert, Shalini K. Vinod, Lois Holloway
arXiv:2606. 18860v1 Announce Type: cross Abstract: Reliable pixel-level uncertainty quantification holds the potential to transform clinical workflows by enabling high-fidelity longitudinal monitoring and distinguishing true pathological changes from artifacts.
By Hana Jebril, Thomas Pinetz, G\"unter Klambauer, Hrvoje Bogunovi\'c
arXiv:2604.12411v2 Announce Type: replace
Abstract: Segmentation models based on deep neural networks demonstrate strong generalization for medical image segmentation. However, they often exhibit ove...
By Qiuyu Tian, Haoliang Sun, Yunshan Wang, Yinghuan Shi, Yilong Yin
arXiv:2604. 15271v3 Announce Type: replace-cross Abstract: Reliable uncertainty estimation is critical for medical image segmentation, where automated contours feed downstream quantification and clinical decision support.
By Tianhao Fu, Austin Wang, Charles Chen, Roby Aldave-Garza, Yucheng Chen
arXiv:2606. 19300v1 Announce Type: cross Abstract: Glioma segmentation in multiparametric MRI is a critical component of treatment planning.
By Xin Ci Wong, Duygu Sarikaya, Kieran Zucker, Marc De Kamps, Nishant Ravikumar
SAUF-Net is a semi‑supervised medical image segmentation framework that learns structure–appearance representations with uncertainty feedback. It decomposes bottleneck features into structural and appearance components, injects them into decoding, and uses auxiliary decoders and a dual‑head discriminator to estimate reliability and uncertainty. Experiments on ISIC‑2016 and Kvasir‑SEG show that SAUF‑Net surpasses state‑of‑the‑art methods, particularly when few labels are available.
By Qin Lu, Zheyang Jing, Yujie Yang, Jianwang Li, Chen Yi, Shaofeng Jiang