arXiv Machine Learning

Cardiovascular Digital Twins from Physics Based to Data Driven Approaches

arXiv:2608. 02135v1 Announce Type: cross Abstract: Cardiovascular digital twins aim to create patient-specific computational models that evolve with clinical data to support diagnosis, prognosis, and therapy optimisation.

arXiv AI
Jun 11

OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins

arXiv:2606. 11264v1 Announce Type: cross Abstract: Health digital twins (HDTs) promise patient-specific modeling and decision support but current approaches remain structurally fragmented: monolithic models that address a single organ or task lack cross-scale fidelity, while system-level twins lack generalizable architectural frameworks.

By Zhaohui Wang, Yu Huang, Jiang Bian
arXiv Machine Learning
Aug 12

Learning Disease-Sensitive Latent Interaction Graphs From Noisy Cardiac Flow Measurements

arXiv:2602. 23035v2 Announce Type: replace Abstract: Cardiac blood flow patterns contain rich information about disease severity and clinical interventions, yet current imaging and computational methods fail to capture underlying relational structures of coherent flow features.

By Viraj Patel, Marko Grujic, Philipp Aigner, Theodor Abart, Marcus Granegger, Deblina Bhattacharjee, Katharine Fraser
arXiv Machine Learning
Jun 25

Neural operator-based digital twins for modeling amyloid-$\beta$ and tau propagation and treatment optimization in Alzheimer's disease

arXiv:2606. 25185v1 Announce Type: new Abstract: Accurately predicting the spatiotemporal evolution of amyloid-$\beta$ and tau proteins at the individual level is critical for improving the diagnosis and treatment of Alzheimer's disease.

By Xiaofeng Xu, Tingting Dan, Zifan Zhou, Bin Li, Guorong Wu, Wenrui Hao
arXiv Machine Learning
Jul 2

Timesynth: A Temporal Fidelity Framework for Health Signal Digital Twins

arXiv:2607. 00431v1 Announce Type: new Abstract: Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost.

By Md Rakibul Haque, Shireen Elhabian, Warren Woodrich Pettine
arXiv AI
Jun 6

Towards World Models in Biomedical Research

arXiv:2606. 05925v1 Announce Type: new Abstract: A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention.

By Guangyu Wang, Jingkun Yue, Siqi Zhang, Yu Liu, Xiaoyu Wang, Mingyuan Meng, Changwei Ji, Zongbo Han, Yulin Wang, Yang Yue, Frank Fu, Ting Chen, Song Wu, Ziwei Liu, Jiangning Song, Ming Li, Gao Huang, Xiaohong Liu, Athanasios Vasilakos, Xingcai Zhang, Ping Zhang, Yong Li