arXiv:2606. 18154v1 Announce Type: new Abstract: Building personalized cardiac electrophysiology (EP) digital twins requires identifying the appropriate model structure for each patient, not merely fitting parameters.
By Ziqi Zhou, Yubo Ye, Sumeet Atul Vadhavka, Linwei Wang, Zhiqiang Tao
arXiv:2606. 15637v1 Announce Type: new Abstract: A digital twin (DT) of a patient-specific heart offers significant potential in personalized medicine.
By Sumeet Vadhavkar, Xiajun Jiang, Yubo Ye, Maryam Toloubidokhti, Linwei Wang
arXiv:2606. 11264v1 Announce Type: cross Abstract: Health digital twins (HDTs) promise patient-specific modeling and decision support but current approaches remain structurally fragmented: monolithic models that address a single organ or task lack cross-scale fidelity, while system-level twins lack generalizable architectural frameworks.
By Zhaohui Wang, Yu Huang, Jiang Bian
arXiv:2602. 23035v2 Announce Type: replace Abstract: Cardiac blood flow patterns contain rich information about disease severity and clinical interventions, yet current imaging and computational methods fail to capture underlying relational structures of coherent flow features.
By Viraj Patel, Marko Grujic, Philipp Aigner, Theodor Abart, Marcus Granegger, Deblina Bhattacharjee, Katharine Fraser
arXiv:2608. 14969v1 Announce Type: new Abstract: We present a physiology-informed digital twin of the human liver designed for longitudinal simulation of liver function and early-stage disease progression.
By Sumaiya Afroz Mila, Sandip Ray
arXiv:2606. 25185v1 Announce Type: new Abstract: Accurately predicting the spatiotemporal evolution of amyloid-$\beta$ and tau proteins at the individual level is critical for improving the diagnosis and treatment of Alzheimer's disease.
By Xiaofeng Xu, Tingting Dan, Zifan Zhou, Bin Li, Guorong Wu, Wenrui Hao
arXiv:2607. 00431v1 Announce Type: new Abstract: Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost.
By Md Rakibul Haque, Shireen Elhabian, Warren Woodrich Pettine
arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.
By Joshua Pickard, Wei Qi, Na Li, Ann Woolley, Lisa Cosimi, Roy Kishony, Deborah Hung
arXiv:2607. 20535v1 Announce Type: cross Abstract: Traditional Predictive Digital Twins often remain geometrically rigid, requiring extensive retraining or fine-tuning whenever the underlying physical domain or boundary conditions change.
By Alicia Tierz, Ic\'iar Alfaro, David Gonz\'alez, El\'ias Cueto
arXiv:2606. 17405v1 Announce Type: new Abstract: Clinical decision support AI systems (CDSASs) must adapt to evolving patient conditions in real-time while adhering to strict safety constraints.
By Xinyu Qin, Anil K. Sood, Ruiheng Yu, Sara Corvigno, Elaine Stur, Lu Wang
arXiv:2606. 05925v1 Announce Type: new Abstract: A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention.
By Guangyu Wang, Jingkun Yue, Siqi Zhang, Yu Liu, Xiaoyu Wang, Mingyuan Meng, Changwei Ji, Zongbo Han, Yulin Wang, Yang Yue, Frank Fu, Ting Chen, Song Wu, Ziwei Liu, Jiangning Song, Ming Li, Gao Huang, Xiaohong Liu, Athanasios Vasilakos, Xingcai Zhang, Ping Zhang, Yong Li
arXiv:2608. 09460v1 Announce Type: new Abstract: Cardiac digital twin research is moving from subject-specific anatomical replicas toward virtual cohorts that represent clinically relevant population subgroups.
By Konstantinos Kevopoulos, Beatrice Moscoloni, Benjamin Alheit, Cameron Beeche, Julio A. Chirinos, Alexander Heinlein, Mathias Peirlinck