arXiv:2608. 09460v1 Announce Type: new Abstract: Cardiac digital twin research is moving from subject-specific anatomical replicas toward virtual cohorts that represent clinically relevant population subgroups.
arXiv:2607. 02564v1 Announce Type: cross Abstract: Computational models of the human heart are widely used to study electromechanical and fluid-dynamical cardiac function and to support applications such as in silico clinical trials.
arXiv:2606. 26718v1 Announce Type: new Abstract: Cardiac magnetic resonance imaging (CMR) captures rich spatiotemporal information about ventricular structure and motion, but conventional risk models use only a few image-derived indices from selected cardiac phases.
arXiv:2607. 25164v1 Announce Type: cross Abstract: A CT examination captures multiple organs, but many biomedical questions concern abnormalities, prognosis, or longitudinal change in a specific organ.
arXiv:2607. 02998v1 Announce Type: cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
arXiv:2606. 03827v1 Announce Type: cross Abstract: In-silico trials of medical devices require the generation of virtual populations of anatomies.
arXiv:2607. 11287v1 Announce Type: cross Abstract: Comprehensive quantification of cardiac structures from computed tomography (CT) remains limited not by data availability but by the scalability of measurements, which makes routine use impractical.
arXiv:2607. 02998v2 Announce Type: replace-cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
arXiv:2608. 19738v1 Announce Type: cross Abstract: Full-cycle biventricular geometry is essential for characterizing cardiac function.
arXiv:2607. 09749v1 Announce Type: cross Abstract: Foundation models have recently emerged as a powerful paradigm for learning transferable representations from large scale biomedical data, yet existing approaches for physiological waveforms primarily optimize reconstruction or forecasting objectives that do not explicitly preserve clinically meaningful waveform morphology.
The paper introduces SV-Cine, a cardiac MRI segmentation framework tailored for single ventricle physiology (SVP). It combines a generative data augmentation pipeline that creates synthetic 3D cardiac meshes and MRI, with a diagnosis-conditioned adaptation of the CineMA foundation model that uses patient-level diagnostic information to improve segmentation. Evaluations on an internal cohort show high Dice scores for left and right ventricles, outperforming nnU-Net, and demonstrate that incorporating diagnosis priors can adapt a pretrained model to specialized SVP tasks.
The paper presents a method for generating cardiac magnetic resonance (CMR) images conditioned on patient metadata using a pretrained latent diffusion model. By encoding structured clinical data and slice position as textual prompts and applying Metadata‑Free Classifier‑Free Guidance, Contrastive Batching, and Inverse‑Frequency Sampling, the authors improve the fidelity of synthetic images, achieving a 57% reduction in Fréchet Inception Distance compared to a baseline without these strategies. Evaluation on 59,058 UK Biobank CMR scans shows better distributional realism and subgroup alignment, though disease‑specific conditioning remains challenging.
The paper presents the first systematic evaluation of out‑of‑distribution generalization for congenital heart disease (CHD) segmentation, using the ImageCHD cohort as a held‑out target. It compares several segmentation architectures under different training regimes, showing that in‑distribution performance is a poor predictor of cross‑cohort robustness: nnU‑Net drops from 0.77 to 0.51 Dice, while SwinUNETR maintains higher performance at 0.67 Dice. Limited target‑domain adaptation with only 11 labeled ImageCHD cases boosts all SwinUNETR variants above 0.76 Dice, highlighting the importance of explicit cross‑dataset testing.