arXiv AI By Joshua Pickard, Wei Qi, Na Li, Ann Woolley, Lisa Cosimi, Roy Kishony, Deborah Hung

EHR-MPC: Inference-Time Control for Sepsis Treatment with Generative Patient Digital Twins

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arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.

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Offline Reinforcement Learning for Hemodynamic Management of Sepsis in the ICU: a MIMIC-IV Study with Dual Off-Policy Evaluation

The dosing of intravenous fluids and vasopressors in sepsis is a sequential decision made under uncertainty and guided largely by clinical judgment, which makes it a natural target for reinforcement learning from historical care. Because a learned policy cannot be trialed on patients, its value must be estimated off-policy, and such estimates can be fragile and optimistic.