arXiv:2606. 18154v1 Announce Type: new Abstract: Building personalized cardiac electrophysiology (EP) digital twins requires identifying the appropriate model structure for each patient, not merely fitting parameters.
By Ziqi Zhou, Yubo Ye, Sumeet Atul Vadhavka, Linwei Wang, Zhiqiang Tao
arXiv:2607. 00431v1 Announce Type: new Abstract: Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost.
By Md Rakibul Haque, Shireen Elhabian, Warren Woodrich Pettine
arXiv:2606. 06094v1 Announce Type: cross Abstract: Advances in computational modeling, neuroimaging, and artificial intelligence are revolutionizing the modeling of neurological disorders for improved diagnostics, prognosis, and treatment planning.
By Shah Pallav Dhanendrakumar, Saikat Pal, Sitikantha Roy
The paper introduces Latent Drift, a generative forecasting framework that predicts slow-evolving neurodegenerative disease progression by learning changes in a compressed semantic representation rather than full-resolution anatomy. It addresses two failure modes—identity collapse and continuous interpolation trap—by removing pixel-level identity from the prediction target and applying Finite Scalar Quantization to suppress high-frequency nuisance fluctuations. Experiments on longitudinal 3D brain MRI demonstrate that Latent Drift outperforms diffusion and autoregressive transformer baselines in both generative fidelity and clinically relevant metrics.
By Yuxiang Feng, Juncheng Wang, Chao Xu, Wenlong Hou, Huihan Wang, Yijie Qian, Yang Liu, Baigui Sun, Yong Liu, Shujun Wang
arXiv:2608. 09460v1 Announce Type: new Abstract: Cardiac digital twin research is moving from subject-specific anatomical replicas toward virtual cohorts that represent clinically relevant population subgroups.
By Konstantinos Kevopoulos, Beatrice Moscoloni, Benjamin Alheit, Cameron Beeche, Julio A. Chirinos, Alexander Heinlein, Mathias Peirlinck
arXiv:2606. 07488v1 Announce Type: new Abstract: Personalized virtual heart simulations face challenges in model personalization and computational cost.
By Ryan Missel, Xiajun Jiang, Linwei Wang