The study proposes a diagnostic-guided approach to choose between stochastic and deterministic longitudinal imaging models based on whether inter-visit changes are driven by disease progression or acquisition variability. Applied to a large, heterogeneous Optos fundus autofluorescence archive, the diagnostic revealed weak time-dependent changes and limited benefit from stochastic models, leading to the development of the deterministic Temporal Retinal U‑Net (TRU). TRU outperformed other classical and deep‑learning comparators on image‑level and eye‑specific progression metrics across held‑out and independent zero‑shot transfer cohorts, though with slightly lower precision in a smaller cross‑vendor cohort.
arXiv:2609.12834v1 Announce Type: new Abstract: Modelling how a disease progresses over time requires longitudinal imaging cohorts, which are scarce and small, whereas cross-sectional data -- one ima...
arXiv:2606. 30417v1 Announce Type: cross Abstract: Forecasting visual fields (VFs) is critical for personalized monitoring and treatment planning in glaucoma.
arXiv:2607. 11656v1 Announce Type: cross Abstract: Accurate diagnostic classification and disease-severity prediction for Alzheimer's disease are hampered by the incompleteness and heterogeneity of real-world clinical data.
arXiv:2606. 24604v1 Announce Type: new Abstract: Longitudinal modelling of Alzheimer's disease progression is clinically useful only if it can describe not just the most likely next diagnosis, but how a patient may evolve over time and how reliable that forecast is.
The paper introduces a reverse spatio‑temporal disease progression model that reconstructs unobserved healthier anatomy from later diseased scans. It employs a two‑stage architecture: a frozen 3D vector‑quantised autoencoder creates a discrete latent space, and a Neural ODE learns continuous‑time dynamics, with a recurrent encoder initializing the latent state from reverse‑ordered observations. Experiments on a synthetic Morpho‑MNIST benchmark and longitudinal Alzheimer’s MRIs show the model can recover unseen prior states and outperform baseline methods in predicting healthy trajectories.
arXiv:2606. 15129v1 Announce Type: cross Abstract: Color fundus photography (CFP) is the mainstay for large-scale retinal screening, yet its diagnostic capacity is constrained by the lack of depth-resolved structural information.
arXiv:2605. 23995v4 Announce Type: replace-cross Abstract: Self-supervised learning (SSL) is increasingly used in medical image analysis to reduce dependence on costly expert annotations by learning transferable representations from unlabeled data.
Color Fundus Photography (CFP) is a primary non-invasive imaging modality for large-scale screening of ophthalmic and systemic diseases. Existing surveys mainly summarize task-specific algorithms, datasets, or preprocessing techniques independently, lacking a unified perspective on their co-evolution with modern artificial intelligence.
Longitudinal modelling of Alzheimer's disease progression is clinically useful only if it can describe not just the most likely next diagnosis, but how a patient may evolve over time and how reliable that forecast is. Most deep learning approaches reduce this problem to single-step classification, treating cognitively normal, mild cognitive impairment, and dementia as flat categories while providing limited insight into how uncertainty accumulates across future visits.
arXiv:2607. 02569v1 Announce Type: cross Abstract: This paper presents a safety-centered empirical evaluation of uncertainty-aware last-layer adaptation for referable diabetic retinopathy screening using RETFound, a self-supervised vision-transformer retinal foundation model used here as a frozen feature encoder, and the public APTOS 2019 and DDR diabetic retinopathy fundus image datasets.
arXiv:2608.28923v1 Announce Type: cross Abstract: Data augmentation is a cornerstone of deep learning pipelines, yet existing strategies treat it as a static, model-agnostic preprocessing step, eithe...
arXiv:2607. 21068v1 Announce Type: new Abstract: Automated detection of vision impairing retina-based ocular conditions from fundus images is important for early screening, timely referral and reducing dependency on specialist-only assessment, for which neural network-based deep learning (DL) models have been widely utilized.