The paper presents an evidence-driven, multi-agent AI system for head and neck proton radiotherapy planning. It combines a DRL-based planning agent that generates multiple treatment plans with an LLM-based conversational agent that refines the chosen plan through natural language interactions. The system, trained on 21 patients, improves instruction-following and domain-specific reasoning, yielding more clinically appropriate trade-offs in patient-specific plan refinement.
arXiv:2608.21864v1 Announce Type: cross Abstract: The current progress of Clinical Vision Large Language Models (C-VLLMs) has substantially improved digital diagnostics, still these frameworks often...
RadOnc-Agent is an AI framework that organizes radiotherapy into four clinical phases and offers 26 callable functions via a conversational interface. A large‑language‑model controller maps clinical intent to schema‑constrained calls, maintains patient and workflow context, and routes requests to specialist services. In evaluations, the system achieved high accuracy in single‑function calls (98.79%) and cross‑stage workflow completions (96.50% scripted, 96.67% real‑patient), demonstrating technical feasibility of LLM‑orchestrated coordination across heterogeneous radiotherapy capabilities.
arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.
arXiv:2609.39566v1 Announce Type: new Abstract: Foundation models can serve as clinical agents through tool-use harnesses. However, conventional medical benchmarks assess reasoning over preselected e...
arXiv:2606. 15504v1 Announce Type: new Abstract: In recent years, the advances of large language models and autonomous agents have revolutionized the healthcare field, facilitating diagnosis and improving treatment results.
ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.
arXiv:2606. 20164v1 Announce Type: cross Abstract: Real-world clinical decision support requires reasoning over heterogeneous and longitudinal patient information rather than answering isolated medical questions.
arXiv:2510. 21324v2 Announce Type: replace Abstract: Chest X-ray (CXR) plays a pivotal role in clinical diagnosis, and a variety of task-specific and foundation models have been developed for automatic CXR interpretation.
arXiv:2610.17426v1 Announce Type: cross Abstract: Clinical decision-making is a sequential process of information collection, clinical inference, and forecasting under partial observability, often wi...
The paper introduces MACD, a Multi-Agent Clinical Diagnosis framework that enables large language models to self‑learn clinical knowledge through a multi‑agent pipeline of summarization, refinement, and application. MACD is extended into a human‑AI collaborative workflow where multiple diagnostician agents consult iteratively, guided by a judge agent and human oversight. Evaluation on the MIMIC‑MACD cohort shows significant gains in diagnostic accuracy—an average 11.6 percentage‑point improvement over authoritative knowledge for open‑weight LLMs and an 18.3‑percentage‑point boost over physician‑only diagnosis in text‑only vignettes.
The paper introduces GUIDER, a method that jointly trains a decision flow controller and a reasoning policy to improve clinical guideline reasoning. GUIDER generates multiple plausible decision flows from guideline supervision, computes process rewards across these flows, and gates them on answer correctness to address both path–answer gaps and path multiplicity. Experiments on MedGUIDE and out‑of‑domain benchmarks show that GUIDER outperforms existing reinforcement learning baselines, achieving higher weighted accuracy and guideline adherence.
STRIVE is a new framework for longitudinal radiology report generation that separates clinical reasoning into distinct Diagnosis, Attribute, and Temporal Change agents, each producing explicit evidence. The Temporal Change agent is refined with a Progression-Aware GRPO reward that differentiates direction-preserving errors from reversals. Verification occurs twice: a Consistency Gate aligns agent outputs before report generation, and a Validation Agent ensures the final report is supported by the aggregated evidence. On the Longitudinal-MIMIC dataset, STRIVE achieves superior clinical efficacy and more than doubles Longitudinal Change Concordance compared to the strongest baseline.