arXiv:2606. 17113v1 Announce Type: new Abstract: Distinguishing causal adverse drug events (ADEs) from spurious correlations remains a central challenge in pharmacovigilance.
arXiv:2604. 16763v3 Announce Type: replace Abstract: Causal inference from electronic health records (EHR) is fundamentally limited by unmeasured confounding: critical clinical states such as frailty, goals of care, and mental status are documented in free-text notes but absent from structured data.
arXiv:2607. 27224v1 Announce Type: cross Abstract: External and synthetic control arms (ECAs) are entering psychiatric drug development, but the field lacks a benchmark that evaluates the properties regulators care about: not only how accurately a method reconstructs untreated trajectories, but whether its uncertainty is calibrated, whether it is robust to the informative observation times common in mental-health records (sicker patients are seen more often), and what false-positive rate it induces in go/no-go trial decisions.
arXiv:2604. 23904v3 Announce Type: replace-cross Abstract: Synthetic tabular data are often evaluated by distributional similarity, privacy distance, or train-on-synthetic-test-on-real predictive performance, but these criteria do not ensure validity for causal inference.
arXiv:2408. 13378v5 Announce Type: replace Abstract: Workflows in drug-target interaction (DTI) assessment require integrating heterogeneous data from predictive models, curated resources, and observations from experimental literature.
arXiv:2608. 20187v1 Announce Type: cross Abstract: Practitioners inferring causality from observational data usually rely on a single method and treat its output as causal truth.
arXiv:2608. 19501v1 Announce Type: cross Abstract: Diagnostic medical tests and devices provide useful information for evaluating the potential benefits and risks of therapeutic treatments.
arXiv:2609.17238v1 Announce Type: cross Abstract: High-dimensional data create challenges for causal effect estimation because identifying the covariates needed for correct model specification become...
arXiv:2608. 08288v1 Announce Type: new Abstract: Estimating counterfactual outcomes over time from longitudinal observational data is central to clinical decision support.
arXiv:2511. 19735v2 Announce Type: replace-cross Abstract: Randomized controlled trials (RCTs)have been the cornerstone of clinical evidence; however, their cost, duration, and restrictive eligibility criteria limit power and external validity.
The study evaluates 12 instruction‑tuned open‑weight LLMs on six causal‑graph benchmarks, testing five prompting strategies and four confidence sources. Findings show that LLMs tend to over‑predict edges, misclassify indirect or reversed edges as direct, and exhibit high over‑confidence, while conventional confidence estimates are unreliable and agreement signals offer limited improvement. The results suggest LLMs should be used as externally validated soft causal priors rather than definitive causal‑structure evidence.
arXiv:2609.06941v1 Announce Type: new Abstract: Causal effect estimation asks how an outcome would change under an intervention, and medicine, economics, and public policy all treat it as a foundatio...
arXiv:2607. 21806v1 Announce Type: new Abstract: Predictive machine learning (ML) models are increasingly used to aid human decision-makers across various high-risk domains such as healthcare and criminal justice.