Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating multi-scale evidence. However, most existing pathology benchmarks evaluate models on pre-cropped patches or pre-extracted slide features, leaving their ability to acquire evidence directly from gigapixel WSIs largely untested.
arXiv:2607.19261v4 Announce Type: replace-cross
Abstract: Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating...
By Dankai Liao, Tianyi Zhang, Yufeng Wu, Xinyue Zhang, Qiaochu Xue, Zeyu Liu, Dachun Zhao, Linghan Cai, Yueming Jin
SlideBank is a training‑free framework that turns each whole‑slide image into a persistent, concept‑indexed evidence bank. It performs coarse‑to‑fine exploration to locate informative regions and multi‑scale views, converts them into explicit morphological observations, and anchors pathology signals to the supporting patches and slide coordinates. During inference, questions are routed to relevant signals and evidence scales, and a confidence‑based cross‑level consensus integrates global, regional, and patch evidence, achieving high accuracy on WSI‑VQA and SlideBench‑BCNB while enabling consistent re‑phrasing and reduced inference cost.
By Beidi Zhao, Gexin Huang, Ciro Zhang, Anqi Li, Yusheng Tan, Chen Zhou, Gang Wang, Zu-hua Gao, Xiaoxiao Li
WILSON is a vision–language foundation model that represents whole‑slide images and multi‑slide patient cases as single multi‑magnification composite images. Trained on about 189,000 Mayo Clinic slides covering 42 organs and 829 diagnostic entities, it outperforms dedicated case‑level models on internal cohorts and matches slide‑level models while using far less compute. Fine‑tuning on triple‑negative breast cancer data improves histologic subtyping and lymphocyte grading, and the model retrieves diagnostic text with high recall and generates captions closer to report references than prior methods.
By Saghir Alfasly, Wataru Uegami, Sobhan Hemati, Wenchao Han, Xiaojia Tang, Kevin Thompson, Daniel Stone, Ghazal Alabtah, Saba Yasir, Michael R. Lucas, Eric W. Klee, Cheryl L. Willman, Judy C. Boughey, Matthew P. Goetz, Krishna R. Kalari, H. R. Tizhoosh
arXiv:2606. 17412v1 Announce Type: cross Abstract: Pathological images are inherently multi-scale, requiring pathologists to integrate evidence from global tissue architecture at low magnification to cellular morphology at higher magnification for accurate diagnosis.
By Chi Phan, Tianyi Zhang, Qiaochu Xue, Yufeng Wu, Dan Hu, Zeyu Liu, Sudong Wang, Yueming Jin
arXiv:2510.23224v2 Announce Type: replace
Abstract: The rapid digitization of histopathology slides has opened new opportunities for computational tools in clinical and research workflows. Content-ba...
By Hongyi Wang, Zhengjie Zhu, Junlin Hou, Jiabo Ma, Fang Wang, Yue Shi, Qiuyu Cai, Jili Wang, Bo Luo, Zhizhong Chai, Zhengyu Zhang, Li Liang, Xiuming Zhang, Yen-Wei Chen, Lanfen Lin, Hao Chen