EviPathBench: Benchmarking Evidence Acquisition and Reasoning in Vision-Language Models for Whole-Slide Pathology
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arXiv:2607. 19261v1 Announce Type: cross Abstract: Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating multi-scale evidence.
Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating multi-scale evidence. However, most existing pathology benchmarks evaluate models on pre-cropped patches or pre-extracted slide features, leaving their ability to acquire evidence directly from gigapixel WSIs largely untested.
SlideBank is a training‑free framework that turns each whole‑slide image into a persistent, concept‑indexed evidence bank. It performs coarse‑to‑fine exploration to locate informative regions and multi‑scale views, converts them into explicit morphological observations, and anchors pathology signals to the supporting patches and slide coordinates. During inference, questions are routed to relevant signals and evidence scales, and a confidence‑based cross‑level consensus integrates global, regional, and patch evidence, achieving high accuracy on WSI‑VQA and SlideBench‑BCNB while enabling consistent re‑phrasing and reduced inference cost.
WILSON is a vision–language foundation model that represents whole‑slide images and multi‑slide patient cases as single multi‑magnification composite images. Trained on about 189,000 Mayo Clinic slides covering 42 organs and 829 diagnostic entities, it outperforms dedicated case‑level models on internal cohorts and matches slide‑level models while using far less compute. Fine‑tuning on triple‑negative breast cancer data improves histologic subtyping and lymphocyte grading, and the model retrieves diagnostic text with high recall and generates captions closer to report references than prior methods.
LanGuSTE is a patch‑selection framework for whole slide image analysis that uses vision‑language models and large language model knowledge. It introduces Cross‑Scale Visual Prompt Tuning to align low‑resolution and high‑resolution patches, and a coarse‑to‑fine selection module that encodes only informative high‑resolution patches. Experiments show LanGuSTE cuts overall processing time to about one‑third of the baseline while matching or surpassing diagnostic performance of exhaustive and state‑of‑the‑art methods.
arXiv:2510.23224v2 Announce Type: replace Abstract: The rapid digitization of histopathology slides has opened new opportunities for computational tools in clinical and research workflows. Content-ba...