The paper introduces a physics-informed deep learning framework that reconstructs 3D coronary geometry from dual-view angiography and predicts velocity and pressure fields using a decoupled network with embedded physical priors. Across 32 patients and four flow conditions, the model achieved a trans‑stenotic pressure‑drop error of 2.02% and velocity/pressure relative‑L2 errors of 0.054 and 0.023, respectively, while matching hospital‑measured FFR with 93.8% diagnostic accuracy. The pipeline completes the full angiography‑to‑hemodynamics conversion in about 20 minutes per patient and supports sparse‑data assimilation for revascularization planning.
By Xi Chen, Jianchuan Yang, Hongde Li, Guangxin He, Qiuyu Ye, Qiang Luo, Mao Chen, Wenqi Hu
arXiv:2604. 27967v2 Announce Type: replace Abstract: Background: We introduce StructGP, a continuous-time multi-task Gaussian process that couples process convolutions with differentiable structure learning to uncover a sparse, ordered directed acyclic graph (DAG) of inter-variable dependencies while preserving principled uncertainty.
By Ivan Lerner, Jean Feydy, Alexandre Kalimouttou, Anita Burgun, Francis Bach
arXiv:2607. 00733v1 Announce Type: cross Abstract: Mechanistic modeling via ordinary differential equations (ODEs) provides interpretable descriptions of complex dynamics and enables inference of underlying mechanisms, which is particularly valuable in clinical settings.
By Hanning Yang, Meropi Karakioulaki, Lennart Purucker, Tim Litwin, Cristina Has, Moritz Hess
The paper introduces Latent Drift, a generative forecasting framework that predicts slow-evolving neurodegenerative disease progression by learning changes in a compressed semantic representation rather than full-resolution anatomy. It addresses two failure modes—identity collapse and continuous interpolation trap—by removing pixel-level identity from the prediction target and applying Finite Scalar Quantization to suppress high-frequency nuisance fluctuations. Experiments on longitudinal 3D brain MRI demonstrate that Latent Drift outperforms diffusion and autoregressive transformer baselines in both generative fidelity and clinically relevant metrics.
By Yuxiang Feng, Juncheng Wang, Chao Xu, Wenlong Hou, Huihan Wang, Yijie Qian, Yang Liu, Baigui Sun, Yong Liu, Shujun Wang
The paper introduces a reverse spatio‑temporal disease progression model that reconstructs unobserved healthier anatomy from later diseased scans. It employs a two‑stage architecture: a frozen 3D vector‑quantised autoencoder creates a discrete latent space, and a Neural ODE learns continuous‑time dynamics, with a recurrent encoder initializing the latent state from reverse‑ordered observations. Experiments on a synthetic Morpho‑MNIST benchmark and longitudinal Alzheimer’s MRIs show the model can recover unseen prior states and outperform baseline methods in predicting healthy trajectories.
By Ulugbek Shernazarov, Moucheng Xu, Inomjon Ramatov
arXiv:2607. 11272v1 Announce Type: cross Abstract: Accurate dengue forecasting is crucial for public health planning, but remains challenging because incidence series are often short, noisy, non-stationary, nonlinear, and often affected by long-range temporal dependence.
By Rahul Goswami, Shinjini Paul, Palash Ghosh, Tanujit Chakraborty
The paper presents an ensemble Kalman–Bucy smoother (EnKBS) for continuous‑time data assimilation of nonlinear dynamical systems, reconstructing conditional distributions from ensemble moments without needing tangent‑linear or adjoint models. It demonstrates that EnKBS achieves exact smoothing mean and covariance in the infinite‑ensemble limit for linear‑Gaussian systems and incorporates regularization techniques like covariance localization and inflation for high‑dimensional problems. The method is applied to Bayesian inference of causal relationships in a dyadic trigger‑feedback model and to an iterative learning algorithm that uncovers the structure and hidden parameters of a reduced‑order model of midlatitude atmospheric circulation, all with small ensembles under partial observations.
By Zhang Jiang (University of Wisconsin-Madison), Marios Andreou (University of Wisconsin-Madison), Sebastian Reich (University of Potsdam), Nan Chen (University of Wisconsin-Madison)
arXiv:2606. 03936v1 Announce Type: new Abstract: Neural operator surrogates (NO) approximate PDE solutions orders of magnitude faster than numerical solvers, but suffer from spectral bias: high-frequency content is systematically attenuated, limiting reliability where fine-scale structure matters.
By Niccol\`o Perrone, Fanny Lehmann, Stefania Fresca, Filippo Gatti
arXiv:2606. 30398v1 Announce Type: new Abstract: Accurately predicting the temporal evolution of clinical biomarkers is crucial for the early diagnosis and management of neurodegenerative diseases such as Alzheimer's disease.
By Yujee Song, Seunghun Baek, Guorong Wu, Won Hwa Kim
Neural operator surrogates (NO) approximate PDE solutions orders of magnitude faster than numerical solvers, but suffer from spectral bias: high-frequency content is systematically attenuated, limiting reliability where fine-scale structure matters. Sparse sensor measurements of the field are often available too, offering pointwise accuracy without spectral distortion but covering only a small fraction of the domain.
arXiv:2602. 23035v2 Announce Type: replace Abstract: Cardiac blood flow patterns contain rich information about disease severity and clinical interventions, yet current imaging and computational methods fail to capture underlying relational structures of coherent flow features.
By Viraj Patel, Marko Grujic, Philipp Aigner, Theodor Abart, Marcus Granegger, Deblina Bhattacharjee, Katharine Fraser
arXiv:2606. 15637v1 Announce Type: new Abstract: A digital twin (DT) of a patient-specific heart offers significant potential in personalized medicine.
By Sumeet Vadhavkar, Xiajun Jiang, Yubo Ye, Maryam Toloubidokhti, Linwei Wang