The paper presents a deep learning super‑resolution framework for 4D flow MRI of carotid arteries, using convolutional block attention modules to focus on clinically relevant spatial features and reduce noise. Trained on 120 patients with 240 stenosed carotid arteries, the model leverages patient‑specific CFD simulations as high‑resolution ground truth. Results show a significant reduction in RMSE and improved reconstruction of complex flow patterns compared to a baseline without attention.
By Ali Mokhtari, Dominik Obrist
arXiv:2610.35396v1 Announce Type: new
Abstract: We evaluated synthetic pretraining and multi-cohort transfer learning for deep learning-based super-resolution of intracranial 4D Flow MRI across heter...
By Oliver Welin Odeback, Susanne Schnell, Patrick Winter, Johan Lundberg, Fredrik Piehl, Tobias Granberg, Alexander Fyrdahl, David Marlevi
FlowMoDL is an unrolled neural network designed for highly accelerated 4D flow MRI reconstruction, optimizing both anatomical magnitude and phase-derived velocity accuracy. It alternates a learned (3+1)D spatiotemporal denoiser with conjugate‑gradient data‑consistency updates, using a dual‑pathway conditioning scheme to handle acceleration factors from 10× to 50×. Trained with a deep‑supervision composite loss that penalizes velocity magnitude and angular errors, FlowMoDL outperforms classical and deep‑learning baselines on the multi‑center CMRx4DFlow dataset, achieving superior gradient‑step efficiency and robust convergence across all acceleration factors.
By Tristan Gottwald, Michelle Bruch, Mubashir-Ul Hassan, Fatma Alickovic, Milan Kloiber, Daniel Tenbrinck, Torsten Panholzer, Melanie Schaller, Jana Hutter
We evaluated synthetic pretraining and multi-cohort transfer learning for deep learning-based super-resolution of intracranial 4D Flow MRI across heterogeneous neurologic cohorts. This mixed prospecti...
The study introduces a physics‑guided, self‑supervised deep learning framework that estimates macromolecular pool fraction (MPF) maps directly from conventional clinical brain MRI sequences (T1‑, T2‑, and FLAIR) without requiring specialized quantitative magnetization transfer scans. By embedding an analytical two‑pool magnetization transfer model and conditioning on acquisition parameters, the method was trained on 7,705 multisite, multivendor MRI sessions and achieved consistent MPF values across vendors and protocols, with a 35.6% reduction in lesions of demyelinating disease compared to normal‑appearing white matter. Cross‑protocol validation in a healthy volunteer showed a mean voxel‑wise absolute difference of 7.7% and a concordance correlation coefficient of 0.888, demonstrating robust cross‑protocol performance.
By Jelmer van Lune, Miha Fuderer, Oscar van der Heide, Matteo Maspero, Martin B. Schilder, Jan Willem Dankbaar, Stefano Mandija, Alessandro Sbrizzi
The study presents a multimodal BrainAGE framework that fuses structural T1-weighted MRI with DeepCBV maps—vascular information synthesized from non‑contrast MRI—to estimate brain age more accurately. Using two separate 3D convolutional neural networks, the combined model achieved a mean absolute error of 3.95 years on cognitively normal controls, outperforming single‑modality models. Saliency analyses showed MRI highlighted white matter and cortical atrophy, while DeepCBV emphasized vascular‑rich regions, and the integrated approach revealed stronger differentiation between stable and progressive MCI, indicating sensitivity to early vascular changes.
By Jordan Jomsky, Zongyu Li, Kay C. Igwe, Yiren Zhang, Max Lashley, Tal Nuriel, Andrew Laine, Scott A. Small, Jia Guo, for the Frontotemporal Lobar Degeneration Neuroimaging Initiative, for the Alzheimer's Disease Neuroimaging Initiative
Magnetic resonance imaging (MRI) super-resolution is vital for improving diagnostic accessibility, yet most methods treat it as a deterministic mapping from a fixed low-resolution input to a high-resolution target. This overlooks a key property of MRI acquisition physics: spatial resolution and signal-to-noise ratio (SNR) are inherently coupled, making any given low-resolution scan merely one of many possible realizations under varying acquisition trade-offs.
arXiv:2605.24625v2 Announce Type: replace
Abstract: Ultra-low-field (ULF) MRI offers portable and accessible neuroimaging but suffers from reduced signal-to-noise ratio and limited spatial resolution...
By Toufiq Musah, Salvatore Calcagno, Federica Proietto Salanitri, Xiaomeng Li, Maruf Adewole, Marawan Elbatel
arXiv:2604. 27277v3 Announce Type: replace-cross Abstract: Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data.
By Yizhou Wu, Shansong Wang, Yuheng Li, Mojtaba Safari, Mingzhe Hu, Chih-Wei Chang, Harini Veeraraghavan, Xiaofeng Yang
This study introduces a self‑supervised, physics‑guided deep‑learning framework that converts standard clinical T1‑, T2‑, and FLAIR MRIs into quantitative T1, T2, and proton‑density maps. Trained on 4,121 scan sessions from four different 3 T scanners over six years, the method produces maps whose white‑ and gray‑matter values fall within literature ranges and shows minimal variation across scanner hardware and acquisition protocols (coefficients of variation ≤ 1.1 %). Voxel‑wise reproducibility is high, with Pearson and concordance correlation coefficients above 0.82 for T1 and T2 and mean relative differences below 6 % for T2.
By Jelmer van Lune, Stefano Mandija, Oscar van der Heide, Matteo Maspero, Martin B. Schilder, Jan Willem Dankbaar, Cornelis A. T. van den Berg, Alessandro Sbrizzi
arXiv:2610.08109v1 Announce Type: new
Abstract: Cardiac magnetic resonance imaging reconstruction aims to recover high-quality images from undersampled acquisitions, enabling faster scans while prese...
By Anam Hashmi, Mayug Maniparambil, Julia Dietlmeier, Kathleen M. Curran, Noel E. O'Connor
arXiv:2606.13315v2 Announce Type: replace
Abstract: MRI self-supervised learning (SSL) has largely emphasized segmentation and dense prediction, while controlled studies of how alternative pretrainin...
By Esra Erg\"un, Hersh Chandarana, Dan Sodickson, Gozde Unal