SpikeSSL is a universal spike inference framework that uses bidirectional IIR state‑space layers inspired by calcium dynamics as its temporal backbone. It incorporates a multi‑modal conditioning encoder to adapt to different calcium indicators, sampling rates, and trace statistics, and provides per‑frame uncertainty estimates. On a benchmark of 33 public datasets, SpikeSSL achieves state‑of‑the‑art performance both in‑domain and in zero‑shot leave‑one‑indicator‑out settings, and a biophysical simulation pipeline further improves cross‑indicator generalization.
arXiv:2604. 04958v3 Announce Type: replace-cross Abstract: Recent work suggests that large-scale, multi-animal modeling can significantly improve neural recording analysis.
arXiv:2607. 23258v1 Announce Type: new Abstract: Large-scale calcium imaging has created an opportunity to build foundation-style models for neural population dynamics, but a central question remains unresolved: \textbf{whether a model pretrained on one collection of recordings can generalize to new datasets, experimental paradigms, and even species.
The paper introduces a neural-operator framework that learns a shared operator across multiple neurons of the same cell type, conditioned on biologically interpretable electrophysiological features. This approach scales biophysically realistic neuron models to large populations while preserving rich cellular dynamics and within-cell-type variability. Evaluation shows accurate reproduction of subthreshold membrane dynamics, spike waveforms, firing-rate responses, and spike timing across major cortical inhibitory neuron types, with predicted electrophysiological feature distributions closely matching detailed simulations and human recordings.
arXiv:2609.06960v1 Announce Type: new Abstract: Invasive neural recordings provide high-fidelity measurements of brain activity, with signals such as intracranial EEG (iEEG) and intracortical spiking...
arXiv:2607. 09754v1 Announce Type: cross Abstract: Large-scale, multi-subject widefield calcium imaging provides unprecedented access to brain-wide cortical dynamics.
arXiv:2607. 14086v1 Announce Type: new Abstract: Robust and accurate neural decoders are integral to neurotechnologies such as brain-computer interfaces and closed-loop experiments.
arXiv:2606. 19888v1 Announce Type: cross Abstract: Modeling long-sequence medical time series data, such as electrocardiograms (ECG), poses significant challenges due to high sampling rates, multichannel signal complexity, inherent noise, and limited labeled data.
arXiv:2412.07264v2 Announce Type: replace-cross Abstract: Understanding complex animal behaviors hinges on deciphering the neural activity patterns within brain circuits, making the ability to foreca...
SpikeMoE introduces a spike-based k‑WTA router that uses lateral inhibition and refractory periods to select the top‑K experts based on discrete spike counts, inspired by hippocampal CA1 competition. The framework combines spiking neural network dynamics with mixture‑of‑experts conditional computation and adds a two‑stage missing‑modality module for robust multimodal processing. Experiments on vision, language, and multimodal tasks show that SpikeMoE matches or surpasses ANN baselines while offering energy‑efficient performance.
The paper presents a discrete generative model for neuronal spiking activity recorded on microelectrode arrays. It uses a shared vocabulary of spatiotemporal motifs learned by a residual vector‑quantized autoencoder and predicts motif occurrence with a factorized masked transformer. Evaluated on 31 assays from human brain organoids and ex vivo hippocampal tissue, the model achieves superior reconstruction and generation performance compared to baselines and shows that motifs are largely reused across assays.
arXiv:2608.21970v1 Announce Type: new Abstract: Two-photon calcium imaging presents a challenging setting for foundation models: image appearance varies substantially across recordings and experiment...
Robust and accurate neural decoders are integral to neurotechnologies such as brain-computer interfaces and closed-loop experiments. Recent work has shown that tokenizing neural data at the spike level facilitates multi-session pretraining and delivers state-of-the-art decoding performance.