arXiv Machine Learning

A discrete generative model of neuronal spiking activity on microelectrode arrays

The paper presents a discrete generative model for neuronal spiking activity recorded on microelectrode arrays. It uses a shared vocabulary of spatiotemporal motifs learned by a residual vector‑quantized autoencoder and predicts motif occurrence with a factorized masked transformer. Evaluated on 31 assays from human brain organoids and ex vivo hippocampal tissue, the model achieves superior reconstruction and generation performance compared to baselines and shows that motifs are largely reused across assays.

arXiv AI
2d ago

SpikeMoE: Brain-Inspired Competitive Routing for Flexible Spiking Mixture-of-Experts

SpikeMoE introduces a spike-based k‑WTA router that uses lateral inhibition and refractory periods to select the top‑K experts based on discrete spike counts, inspired by hippocampal CA1 competition. The framework combines spiking neural network dynamics with mixture‑of‑experts conditional computation and adds a two‑stage missing‑modality module for robust multimodal processing. Experiments on vision, language, and multimodal tasks show that SpikeMoE matches or surpasses ANN baselines while offering energy‑efficient performance.

By Xiaoli Liu, Yujie Liang, Jialin Li, Malu Zhang
arXiv Machine Learning
Sep 15

Exploring napping paradigm for Recurrent Spiking Neural Networks

The paper proposes a biologically inspired micro‑sleep technique called napping for recurrent spiking neural networks, combining proportional weight scaling with continuous stochastic membrane activity. Experiments on an unsupervised SNN trained with trace‑based STDP on Gabor‑preprocessed MNIST show that well‑tuned napping can match the classification accuracy of conventional weight normalization while offering different clustering characteristics. The study suggests that napping may be preferable when representational structure is more important than raw classification speed, despite its higher simulation cost.

By Andreas Massey, Stefano Nichele, Aliaksandr Hubin
arXiv AI
Jun 2

Rare Events, Real Signals: Functional Ensembles as Units of Computation in Deep Spiking Networks

arXiv:2606. 00073v1 Announce Type: cross Abstract: We investigate how internal representations emerge across hierarchical processing systems by introducing a neuroscience-inspired framework for analyzing deep spiking neural networks (SNN) through the lens of functional connectivity.

By Aditi Aravind, Konstantinos Ladakis, Mario Alexios Savaglio, Stelios M. Smirnakis, Maria Papadopouli
arXiv Computation and Language
Sep 7

Large Language Models with At Most One Spike per Neuron

The paper presents a spiking neural network (SNN) approach that uses time-to-first-spike (TTFS) coding to limit each neuron to at most one spike per time window, enabling energy-efficient large language models (LLMs). A reference-based strategy is introduced to encode the four core LLM components—embedding layers, layer normalization, attention-related operations, and dropout—allowing the construction of a fully TTFS-based SNN architecture trained end-to-end. Experiments on BERT and GPT-2 show performance comparable to artificial neural network (ANN) counterparts on natural language understanding and common-sense reasoning, while achieving a 1.5‑billion‑parameter spiking LLM and providing an estimate of spike-related energy consumption.

By Zhuoya Zhao, Parsa Omidi, Aref Jafari, Richard Naud
arXiv Computer Vision
Sep 3

Progression as Latent Drift: Generative Forecasting of Slow-Evolving Pathologies

The paper introduces Latent Drift, a generative forecasting framework that predicts slow-evolving neurodegenerative disease progression by learning changes in a compressed semantic representation rather than full-resolution anatomy. It addresses two failure modes—identity collapse and continuous interpolation trap—by removing pixel-level identity from the prediction target and applying Finite Scalar Quantization to suppress high-frequency nuisance fluctuations. Experiments on longitudinal 3D brain MRI demonstrate that Latent Drift outperforms diffusion and autoregressive transformer baselines in both generative fidelity and clinically relevant metrics.

By Yuxiang Feng, Juncheng Wang, Chao Xu, Wenlong Hou, Huihan Wang, Yijie Qian, Yang Liu, Baigui Sun, Yong Liu, Shujun Wang