arXiv Machine Learning By Md Sayed Tanveer, Mohammed A. Mostajo-Radji, Ge Wang

A discrete generative model of neuronal spiking activity on microelectrode arrays

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The paper presents a discrete generative model for neuronal spiking activity recorded on microelectrode arrays. It uses a shared vocabulary of spatiotemporal motifs learned by a residual vector‑quantized autoencoder and predicts motif occurrence with a factorized masked transformer. Evaluated on 31 assays from human brain organoids and ex vivo hippocampal tissue, the model achieves superior reconstruction and generation performance compared to baselines and shows that motifs are largely reused across assays.

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