arXiv AI By Marc Rodr\'iguez, Grzegorz Skorupko, Nay Aung, Steffen E Petersen, Karim Lekadir, Polyxeni Gkontra

Metadata-Aware Adaptation of a Generative Foundation Model for Conditional CMR Synthesis

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The paper presents a method for generating cardiac magnetic resonance (CMR) images conditioned on patient metadata using a pretrained latent diffusion model. By encoding structured clinical data and slice position as textual prompts and applying Metadata‑Free Classifier‑Free Guidance, Contrastive Batching, and Inverse‑Frequency Sampling, the authors improve the fidelity of synthetic images, achieving a 57% reduction in Fréchet Inception Distance compared to a baseline without these strategies. Evaluation on 59,058 UK Biobank CMR scans shows better distributional realism and subgroup alignment, though disease‑specific conditioning remains challenging.

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