EHR-MPC: Inference-Time Control for Sepsis Treatment with Generative Patient Digital Twins
arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.
arXiv:2301. 07210v5 Announce Type: replace-cross Abstract: Digital twins are simulation-based models designed to predict how a real-world process will evolve in response to interventions.
arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.
arXiv:2607. 14940v1 Announce Type: new Abstract: We study causal inference under outcome interference for sequential, observational settings.
CausalProfiler is a synthetic benchmark generator designed to evaluate causal machine learning (Causal ML) methods more rigorously and transparently. It randomly samples causal models, data, queries, and ground truths based on explicit design choices across observation, intervention, and counterfactual reasoning levels, providing coverage guarantees and transparent assumptions. The authors demonstrate its utility by testing several state‑of‑the‑art methods under diverse conditions, both within and outside the identification regime, highlighting the insights CausalProfiler can reveal.
Deep learning has enabled significant advances in time-series causal inference, yet progress remains constrained by the lack of realistic benchmarks with observable counterfactual outcomes. Existing datasets either rely on real-world observations without ground-truth counterfactuals or on simplified simulations that fail to capture complex causal dynamics.
arXiv:2607. 11508v1 Announce Type: cross Abstract: Causal discovery, the process of recovering underlying causal structures from observational data, is a fundamental pursuit across scientific disciplines.
arXiv:2607. 21806v1 Announce Type: new Abstract: Predictive machine learning (ML) models are increasingly used to aid human decision-makers across various high-risk domains such as healthcare and criminal justice.
arXiv:2608. 10339v1 Announce Type: cross Abstract: Hospital quality improvement (QI) programs routinely face multiple candidate interventions to optimize hospital flow, but existing methods struggle to estimate and rank the causal effects of such interventions.
arXiv:2606. 05692v1 Announce Type: new Abstract: Deep learning has enabled significant advances in time-series causal inference, yet progress remains constrained by the lack of realistic benchmarks with observable counterfactual outcomes.
arXiv:2607. 00431v1 Announce Type: new Abstract: Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost.
arXiv:2606. 07865v1 Announce Type: cross Abstract: Scientific machine learning is limited less by model size than by the data it is trained on.
arXiv:2604. 16763v3 Announce Type: replace Abstract: Causal inference from electronic health records (EHR) is fundamentally limited by unmeasured confounding: critical clinical states such as frailty, goals of care, and mental status are documented in free-text notes but absent from structured data.
arXiv:2607. 18164v1 Announce Type: cross Abstract: Digital Twins rely on surrogate models to mirror physical systems in real time, yet these models can degrade as operating conditions evolve, a phenomenon known as concept drift.